PMID: 6971102Mar 1, 1981Paper

Production of agglutinators and rheumatoid factors in plasma cells of rheumatoid and nonrheumatoid synovial tissues

Arthritis and Rheumatism
K FehrA Böni

Abstract

Immunohistochemical studies were performed in synovial tissues from 40 patients with rheumatoid arthritis (RA), 9 with juvenile rheumatoid arthritis (JRA), 7 with psoriatic arthritis, and 4 with various rheumatic diseases. Overall synthesis of IgG- and/or IgM-rheumatoid factor (RF) was found in all patients with seropositive RA and JRA, in 75% of patients with seronegative RA, and in 1 patient with psoriatic arthritis. Agglutinator producing cells were found in 77% of the samples from seropositive RA and in 44% and 56% from seronegative RA and JRA patients, respectively. The percentage of IgG plasma cells synthesizing one or more of the 5 types of agglutinators studied was approximately 10% of plasma cells synthesizing IgG-RF. Intercellular and intracellular immune complex deposits were also found in patients with seropositive and seronegative RA and JRA. These findings suggest that synthesis of agglutinators by synovial tissue plasma cells of RA and JRA patients is a distinct--but definitely less prominent--function than that of RF synthesis.

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Citations

Mar 1, 1990·Cytotechnology·D W KarlM C Flickinger
Jan 1, 1984·Rheumatology International·O J MellbyeJ H Dobloug
May 1, 1982·Molecular Immunology·A BaiciK Fehr
Dec 1, 1985·The Journal of Experimental Medicine·F A NardellaM Mannik
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Jun 8, 2004·Arthritis Research & Therapy·Gregg J Silverman, Dennis A Carson
Jan 1, 1987·Scandinavian Journal of Rheumatology. Supplement·A Martini
Sep 20, 2011·Journal of Autoimmunity·Jürgen HaasBrigitte Wildemann
Nov 1, 1982·Scandinavian Journal of Immunology·T EgelandJ B Natvig
Dec 1, 1982·Scandinavian Journal of Immunology·A BaiciK Fehr
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Mar 15, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Florence AnquetilMireille Sebbag
Jan 1, 1987·Acta Medica Scandinavica. Supplementum·L KlareskogK Rubin
Feb 1, 1992·Clinical and Experimental Immunology·N C WoodG W Duff

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