Production of allergen-specific immunotherapeutic agents for the treatment of food allergy.

Critical Reviews in Biotechnology
Jeppe Madura LarsenKatrine Lindholm Bøgh

Abstract

Allergen-specific immunotherapy (IT) is emerging as a viable avenue for the treatment of food allergies. Clinical trials currently investigate raw or slightly processed foods as therapeutic agents, as trials using food-grade agents can be performed without the strict regulations to which conventional drugs are subjected. However, this limits the ability of standardization and may affect clinical trial outcomes and reproducibility. Herein, we provide an overview of methods used in the production of immunotherapeutic agents for the treatment of food allergies, including processed foods, allergen extracts, recombinant allergens, and synthetic peptides, as well as the physical and chemical processes for the reduction of protein allergenicity. Commercial interests currently favor producing standardized drug-grade allergen extracts for therapeutic use, and clinical trials are ongoing. In the near future, recombinant production could replace purification strategies since it allows the manufacturing of pure, native allergens or sequence-modified allergens with reduced allergenicity. A recurring issue within this field is the inadequate reporting of production procedures, quality control, product physicochemical characteristics, allerge...Continue Reading

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May 11, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Oliver PfaarStefan Schülke
Aug 25, 2021·Molecular Biology Reports·Nur Farah Hani AzemiHaidr Msahir Ateshan

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