Production of amphiregulin and recovery from influenza is greater in males than females

Biology of Sex Differences
Meghan S VermillionSabra L Klein

Abstract

Amphiregulin (AREG) is an epidermal growth factor that is a significant mediator of tissue repair at mucosal sites, including in the lungs during influenza A virus (IAV) infection. Previous research illustrates that males of reproductive ages experience less severe disease and recover faster than females following infection with IAV. Whether males and females differentially produce and utilize AREG for pulmonary repair after IAV infection was investigated using murine models on a C57BL/6 background and primary mouse and human epithelial cell culture systems. Following sublethal infection with 2009 H1N1 IAV, adult female mice experienced greater morbidity and pulmonary inflammation during the acute phase of infection as well as worse pulmonary function during the recovery phase of infection than males, despite having similar virus clearance kinetics. As compared with females, AREG expression was greater in the lungs of male mice as well as in primary respiratory epithelial cells derived from mouse and human male donors, in response to H1N1 IAVs. Internalization of the epidermal growth factor receptor (EGFR) was also greater in respiratory epithelial cells derived from male than female mice. IAV infection of Areg knock-out (Areg-...Continue Reading

References

Mar 1, 1997·Journal of Applied Physiology·C G TankersleyS R Kleeberger
Apr 24, 1999·FEBS Letters·J T JonesM X Sliwkowski
Feb 3, 2005·Gastroenterology·Carmen BerasainMatías A Avila
Mar 9, 2005·The Journal of Biological Chemistry·Carmen BerasainMatías A Avila
Mar 23, 2005·In Vitro Cellular & Developmental Biology. Animal·Regina K RoweAndrew Pekosz
Dec 16, 2006·Science·Dietmar M ZaissTim R Mosmann
Dec 21, 2006·Archives of Surgery·Christopher G EngelandPhillip T Marucha
Feb 6, 2007·Clinics in Dermatology·Stephen C GilliverGillian S Ashcroft
Nov 30, 2007·The Biochemical Journal·Kathryn A SternNancy L Lill
Jul 18, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Maria J PerugorriaMatias A Avila
Mar 12, 2009·Experimental Cell Research·Alexander Sorkin, Lai Kuan Goh
Dec 23, 2009·PLoS Medicine·Olivier Neyrolles, Lluis Quintana-Murci
Mar 20, 2010·The Journal of General Virology·Benjamin G HaleAdolfo García-Sastre
Jun 15, 2011·Influenza and Other Respiratory Viruses·Alexander N LarcombePeter D Sly
Aug 5, 2011·The American Journal of Tropical Medicine and Hygiene·Xinyu ZhangZhenhua Yang
Oct 25, 2011·The Journal of Infectious Diseases·Aras KadiogluMarco R Oggioni
Jan 28, 2014·Seminars in Cell & Developmental Biology·Carmen Berasain, Matías A Avila
May 13, 2014·American Journal of Respiratory Cell and Molecular Biology·Francine L KellyScott M Palmer
Jun 27, 2014·The Journal of Infectious Diseases·Marylyn M Addo, Marcus Altfeld
Jun 27, 2014·The Journal of Infectious Diseases·Gülsah Gabriel, Petra Clara Arck
Aug 5, 2014·The Journal of Investigative Dermatology·Chantal MeulenbroeksDietmar M W Zaiss
Aug 6, 2015·Proceedings of the National Academy of Sciences of the United States of America·Laurel A MonticelliDavid Artis
Sep 1, 2015·Cell·Nicholas ArpaiaAlexander Y Rudensky
Sep 1, 2015·Vaccine·Julia HoffmannGülsah Gabriel
Dec 19, 2015·Respirology : Official Journal of the Asian Pacific Society of Respirology·Deepa Raghavan, Raksha Jain

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Citations

Jun 23, 2020·PLoS Pathogens·Sabra L KleinFranck Mauvais-Jarvis
Oct 10, 2018·Seminars in Immunopathology·Landon G Vom Steeg, Sabra L Klein
Dec 25, 2019·Cold Spring Harbor Perspectives in Medicine·Rebekah HonceStacey Schultz-Cherry
Nov 17, 2020·Frontiers in Medicine·Mahmood Yaseen HachimRifat Hamoudi
Oct 20, 2020·Current Opinion in Physiology·Katherine S Forsyth, Montserrat C Anguera
Apr 8, 2021·Nature Reviews. Microbiology·Tim FlerlageStacey Schultz-Cherry
May 23, 2021·Journal of Ovarian Research·Osman A DufailuMeshach Asare-Werehene
Aug 28, 2021·International Journal of Environmental Research and Public Health·Faisal F AlamriFaleh Alqahtani
Aug 24, 2021·The Journal of Infectious Diseases·Luca T GiurgeaMatthew J Memoli
Jun 4, 2021·Annual Review of Virology·Rebecca L Ursin, Sabra L Klein

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Methods Mentioned

BETA
PCR
confocal microscopy

Software Mentioned

ImageJ
Zen
Volocity
FIJI

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