PMID: 2116377Aug 1, 1990Paper

Production of arachidonic and linoleic acid metabolites by guinea pig tracheal epithelial cells

M J OosthuizenF P Nijkamp


Pulmonary epithelial cells may be responsible for regulating airway smooth muscle function, in part by release of fatty acid-derived mediators. Incubation of isolated guinea pig tracheal epithelial cells with radiolabeled arachidonic acid (AA) leads to the production of 5- and 15-hydroxyeicosatetraenoic acid (5- and 15-HETE) and smaller amounts of leukotriene (LT) B4 and C4 and 12-hydroxyheptadecatrienoic acid (HHT). Epithelial cells also are able to release linoleic acid (LA) metabolites. Incubation with radiolabeled linoleic acid leads to the formation of 9- and 13-hydroxyoctadecadienoic acid (9- and 13-HODE). The biological significance of these mediators produced by epithelial cells is discussed.


Jan 1, 1985·Journal of Cardiovascular Pharmacology·P M VanhoutteN A Flavahan
Oct 23, 1985·Biochimica Et Biophysica Acta·M ClaeysD H Nugteren
Dec 1, 1985·Journal of Applied Physiology·P M O'ByrneJ A Nadel
Feb 1, 1986·Pharmacological Research Communications·M P AbbracchioC Omini
Jan 1, 1988·Progress in Lipid Research·A A SpectorS A Moore
Jan 1, 1986·Experimental Lung Research·G L XuT Eling
Jul 31, 1987·Biochemical and Biophysical Research Communications·B N SettyM J Stuart
Jan 1, 1988·General Pharmacology·T E ElingR Danilowicz
Mar 1, 1986·British Journal of Pharmacology·M C Holroyde
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·P S AisenG Weissmann
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J A HunterM J Holtzman
Mar 1, 1985·Journal of Applied Physiology·N A FlavahanP M Vanhoutte
Apr 1, 1985·The American Review of Respiratory Disease·L A LaitinenT Haahtela
Nov 1, 1985·British Journal of Pharmacology·P J BarnesJ B Palmer
Jan 1, 1984·Prostaglandins, Leukotrienes, and Medicine·J VerhagenP L Bruynzeel

❮ Previous
Next ❯


May 17, 1991·European Journal of Pharmacology·P A HenricksF P Nijkamp
Feb 1, 1992·The International Journal of Biochemistry·A P KulkarniI S Richards
Jan 1, 1997·Research in Immunology·D B Jacoby
Feb 25, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jyothi M VeigasGabriel Fernandes
Apr 16, 2008·European Journal of Pharmacology·Alma J NautaFrank A Redegeld

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.