PMID: 2116377Aug 1, 1990Paper

Production of arachidonic and linoleic acid metabolites by guinea pig tracheal epithelial cells

Inflammation
M J OosthuizenF P Nijkamp

Abstract

Pulmonary epithelial cells may be responsible for regulating airway smooth muscle function, in part by release of fatty acid-derived mediators. Incubation of isolated guinea pig tracheal epithelial cells with radiolabeled arachidonic acid (AA) leads to the production of 5- and 15-hydroxyeicosatetraenoic acid (5- and 15-HETE) and smaller amounts of leukotriene (LT) B4 and C4 and 12-hydroxyheptadecatrienoic acid (HHT). Epithelial cells also are able to release linoleic acid (LA) metabolites. Incubation with radiolabeled linoleic acid leads to the formation of 9- and 13-hydroxyoctadecadienoic acid (9- and 13-HODE). The biological significance of these mediators produced by epithelial cells is discussed.

References

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Citations

May 17, 1991·European Journal of Pharmacology·P A HenricksF P Nijkamp
Feb 1, 1992·The International Journal of Biochemistry·A P KulkarniI S Richards
Jan 1, 1997·Research in Immunology·D B Jacoby
Feb 25, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jyothi M VeigasGabriel Fernandes
Apr 16, 2008·European Journal of Pharmacology·Alma J NautaFrank A Redegeld

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