PMID: 6969889Nov 1, 1980Paper

Production of auto-anti-idiotypic antibody during the normal immune response: changes in the auto-anti-idiotypic antibody response and the idiotype repertoire associated with aging

Proceedings of the National Academy of Sciences of the United States of America
E A GoidlG W Siskind

Abstract

Hapten-augmentable plaque-forming cells (PFC) are cells whose secretion of antibody is specifically inhibited by surface-bound auto-anti-iodotype antibody that can be displaced by hapten. This study showed that the percentage of hapten-augmentable PFC present in mice during the primary response to trinitrophenylated Ficoll (TNP-F) increases with age. The data suggest that there is a relative increase in the auto-anti-idiotypic antibody response with age and therefore a greater down-regulation of antibody production. The effect of age on idiotype expression was also studied. Hapten-reversible inhibition of plaque formation was used as an assay for anti-inhibition of plaque formation was used as an assay for anti-idiotype antibody and idiotype-bearing antibody-secreting cells. Sera from aged (21- to 22-month-old) C57BL/6 mice immunized with TNP-F significantly inhibited plaque formation, in a hapten-reversible manner, by spleen cells from 81% of TNP-F-immunized aged mice. However, these sera inhibited plaque formation by cells from only 50% of similarly immunized young adult (6- to 8-week-old) mice and 20% of immature (3- to 4-week-old) syngeneic mice. Similarly, sera from TNP-F-immunized young adult or immature mice inhibited fo...Continue Reading

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Citations

May 1, 1991·Mechanisms of Ageing and Development·Y TomerA Globerson
Mar 17, 1995·Mechanisms of Ageing and Development·M HosonoT Hosokawa
Jan 1, 1983·Molecular Aspects of Medicine·N R FaridJ C Bear
Jan 1, 1986·Developmental and Comparative Immunology·M HosonoY Katsura
Jul 15, 1998·Mechanisms of Ageing and Development·A M de FariaN M Vaz
Feb 26, 2000·Vaccine·M E Weksler
Sep 24, 2009·Immunology and Cell Biology·Daisuke HidaKen-Ichi Isobe
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·T TsudaM E Weksler
Jan 1, 1988·Experimental Aging Research·D G Hazzard, J Soban
Jan 1, 1982·Immunogenetics·P IvanyiC J Kröse
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·G DoriaL Adorini
Oct 15, 1988·Cellular Immunology·V UdhayakumarP S Nagarkatti
Jan 1, 1982·Annals of the New York Academy of Sciences·G W SiskindE A Goidl
Nov 1, 1982·Journal of the American Geriatrics Society·M E Weksler
Jun 30, 1983·Annals of the New York Academy of Sciences·M R Szewczuk, A W Wade
Sep 16, 2000·Rheumatic Diseases Clinics of North America·R L Yung
Aug 1, 1989·Cellular Immunology·G DoriaD Frasca
Mar 1, 1982·Cellular Immunology·R A WinchurchA Munster
Jun 12, 2002·The American Journal of Pathology·Vincent K TsiagbeNicholas M Ponzio
Aug 1, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A M FariaN M Vaz
Jan 1, 1995·International Reviews of Immunology·N R Klinman, G J Thorbecke

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