Production of collagen micro- and nanofibers for potential drug-carrier systems

Journal of Enzyme Inhibition and Medicinal Chemistry
Onur Aras, Murat Kazanci

Abstract

Two different nano- and micro-collagen fiber production methods are introduced and discussed. First one is the electrospinning method, that is very common technique to produce nanofibers from different polymeric solutions and recently collagen solutions are employed to produce nanofibers for different biomedical applications. This technique is extremely versatile method to produce nanofibers in a relatively short time, easy to control the fiber diameter and orientation with small pore sizes and a high surface area. The second method is self-assembly of collagen micro-fibers by co-extrusion method. The collagen fibers are obtained without any cross-linker, by using mainly ionic interactions. We demonstrated that self-assembled collagen fibers have well preserved their native structure (0.90 PP-II fraction), when compared with electrospun collagen fibers (0.38 PP-II fraction). However, it was only possible to produce collagen fibers with nanodimensions by using electrospinning method.

References

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Dec 22, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Jochen BürckMurat Kazanci

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Citations

Jun 30, 2016·Journal of Biomedical Materials Research. Part a·Kuwabo MubyanaDavid T Corr
Mar 2, 2021·Materials Science & Engineering. C, Materials for Biological Applications·John RedmondNicholas J Dunne

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