Production of cytokines during interaction of peripheral blood mononuclear cells with autologous ovarian cancer cells or benign ovarian tumour cells

Scandinavian Journal of Immunology
M NowakH Tchorzewski


Cytokines produced by tumour and immune cells may play a significant role in a modulation of immune cells response against tumour. We investigated an ability of peripheral blood mononuclear cells (PBMC) of patients with early and advanced stages of ovarian cancer and from non-cancer patients to produce various cytokines in the presence or absence of autologous ovarian cancer (OC) cells or benign ovarian tumour (BOT) cells. Activated PBMC of patients with advanced stage of cancer produced slight amount of interferon gamma (IFN-gamma) and what's more, the production of IFN-gamma was decreased in the presence of OC cells. PBMC of patients with ovarian cancer or benign ovarian tumour generated comparable amounts of interleukin 6 and 10 (IL-6, IL-10), and transforming growth factor beta1 (TGF-beta1). PBMC of the patients with cancer produced higher amount of tumour necrosis factor alpha (TNF-alpha) than PBMC of non-cancer patients. We demonstrated here that the reciprocal contact of OC cells from advanced cancer with autologous PBMC altered the direction of produced cytokines and leads to the down-regulation of IFN-gamma and TNF-alpha as well as to up-regulation of immunosuppressive (IL-10, TGF-beta1) and pro-inflammatory (IL-6) cyt...Continue Reading


Mar 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·R A BurgerT Gatanaga
Jul 1, 1997·Gynecologic Oncology·C TempferC Kainz
Jun 25, 1998·International Journal of Cancer. Journal International Du Cancer·C Asselin-PaturelF Mami-Chouaib
Oct 21, 2000·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J L BenedetS Pecorelli
Apr 20, 2001·Cytokine & Growth Factor Reviews·P C SmithE T Keller
Aug 21, 2001·BJOG : an International Journal of Obstetrics and Gynaecology·A D SantinG P Parham
Nov 18, 2004·American Journal of Obstetrics and Gynecology·Christian MarthGünter Daxenbichler
Mar 23, 2005·Immunity·Alexandre CorthayBjarne Bogen
Jul 13, 2005·Cancer Immunology, Immunotherapy : CII·K L Knutson, M L Disis
Aug 23, 2005·Journal of Reproductive Immunology·Shin-Heng ChiouHo Hong-Nerng
Mar 7, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Peter SzlosarekFrances R Balkwill
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lori Broderick, Richard B Bankert
Aug 24, 2006·Breast Cancer Research and Treatment·Heike Knüpfer, Rainer Preiss
Sep 5, 2006·Cancer Metastasis Reviews·Sonia B Jakowlew
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May 2, 2008·Cancer Letters·Antonio SicaAlberto Mantovani
Jun 21, 2008·Scandinavian Journal of Immunology·M KlinkZ Sulowska

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