Production of formyl-CoA during peroxisomal alpha-oxidation of 3-methyl-branched fatty acids

FEBS Letters
K CroesM Casteels

Abstract

alpha-Oxidation of 3-methyl-substituted fatty acids was studied in purified rat liver peroxisomes. The experiments revealed that formyl-CoA is formed during the alpha-oxidation process. The amount of formyl-CoA found constituted 2-5% of the amount of formate formed. Under the conditions used, no activation of exogenously added formate occurred in purified peroxisomes, whereas 95.5% of added synthetic formyl-CoA was converted to formate. These data indicate that during alpha-oxidation first formyl-CoA is formed, which is then hydrolysed to formate.

References

Jul 1, 1992·Archives of Biochemistry and Biophysics·S HuangG P Mannaerts
Jan 1, 1995·Analytical Biochemistry·V B RajgarhiaW R Strohl

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Citations

Nov 25, 1998·Molecular Aspects of Medicine·R J Wanders, J M Tager
Oct 10, 2001·Progress in Lipid Research·N M Verhoeven, C Jakobs
Jun 20, 2003·Progress in Lipid Research·Mridul MukherjiMatthew D Lloyd
Mar 14, 2003·Biochimica Et Biophysica Acta·Ronald J A WandersMatthew D Lloyd
Apr 16, 2003·European Journal of Biochemistry·Minne CasteelsPaul P Van Veldhoven
Jun 8, 2006·Annual Review of Biochemistry·Ronald J A Wanders, Hans R Waterham
Jun 19, 2010·Journal of Lipid Research·Paul P Van Veldhoven
May 11, 2013·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Angela CintolesiRamon Gonzalez
Mar 21, 2012·The Biochemical Journal·Guo-Fang ZhangHenri Brunengraber
Aug 29, 2006·Biochimica Et Biophysica Acta·Gerbert A Jansen, Ronald J A Wanders
Aug 19, 2003·Journal of Lipid Research·Veerle FoulonPaul P Van Veldhoven
Jan 1, 1998·Journal of Cellular Biochemistry·Udo Seedorf
Dec 4, 2010·The Journal of Biological Chemistry·Stephanie R HarrisHenri Brunengraber
Sep 28, 2005·The Journal of Biological Chemistry·Michael A McDonoughChristopher J Schofield

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