Production of gastrin releasing peptide by medullary carcinoma of the thyroid. An immunohistochemical study

Virchows Archiv. A, Pathological Anatomy and Histopathology
T KameyaN Yanaihara

Abstract

Forty medullary carcinomas of the thyroid (MCT) with documented calcitonin (CT) production were studied immunohistochemically for the production of gastrin releasing peptide (GRP), a mammalian counterpart of amphibian bombesin. GRP-positive cells, revealed by an unlabelled peroxidase-antiperoxidase immunoenzyme histochemistry were found in 81% (34/40) of the MCTs. Variable numbers of tumor cells in positive MCTs were immunostained for GRP. In 3 cases with Sipple's syndrome, cells in scattered microscopic MCT nodules and hyperplastic intrafollicular C cells of the thyroid were frequently positive for GRP as well as for CT. Non-neoplastic C cells (or CT-positive cells) of the human thyroids were also positive for GRP. In the neoplastic and non-neoplastic C cell system, some cells were confirmed to be immunoreactive with both anti-GRP and anti-CT. All these findings indicate that GRP and CT are closely associated peptide hormones produced by the C cell system.

References

Aug 22, 1977·Histochemistry·S Van NoordenA G Pearse
Jun 29, 1978·Nature·J WhartonA G Pearse
Dec 1, 1978·General and Comparative Endocrinology·J LechagoJ H Walsh
Sep 15, 1979·Experientia·P SkrabanekD Powell
Sep 12, 1979·Biochemical and Biophysical Research Communications·T J McDonaldV Mutt
Oct 1, 1970·Metabolism: Clinical and Experimental·K E MelvinJ R Givens
Aug 9, 1973·Virchows Archiv. A: Pathology. Pathologische Anatomie·G BussolatiC Bordi
Aug 30, 1973·The New England Journal of Medicine·H J WolfeA H Tashjian
Oct 22, 1970·The New England Journal of Medicine·A H TashijanC S Hill
Mar 1, 1966·Journal of Clinical Pathology·E D Williams
Apr 1, 1966·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R C Graham, M J Karnovsky
Dec 1, 1981·The Journal of Clinical Endocrinology and Metabolism·S M WoodS R Bloom
Jan 1, 1981·Peptides·N YanaiharaT Iwanaga
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M D ErismanL H Lazarus
Jan 1, 1959·The Journal of Clinical Endocrinology and Metabolism·J B HAZARDG CRILE

❮ Previous
Next ❯

Citations

Jan 1, 1986·Journal of Cancer Research and Clinical Oncology·H ItoE Tahara
Jan 1, 1983·Virchows Archiv. A, Pathological Anatomy and Histopathology·Y TsutsumiN Yanaihara
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·T SuzukiA Miyauchi
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·A OoiN Yanaihara
Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·N Kimura, N Sasano
Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·C H KendallJ M Polak
Jul 15, 1987·Experientia·E SolciaE Silini
Jul 31, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·E KaiserW Worofka
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T GrunditzF Sundler
Jan 1, 1991·Cytopathology : Official Journal of the British Society for Clinical Cytology·M E MendonçaJ Soares
Nov 28, 2002·International Journal of Cancer. Journal International Du Cancer·Theresia WeberMagnus von Knebel Doeberitz Mv
Jan 1, 1988·Annals of the New York Academy of Sciences·E SolciaJ M Polak
Jan 1, 1988·Annals of the New York Academy of Sciences·Y Tsutsumi
Jan 1, 1988·Annals of the New York Academy of Sciences·M E Sunday
Dec 1, 1985·The Journal of Pathology·D G Bostwick, K G Bensch
Oct 19, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Marina Parra-RobertRafael Molina

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.