Production of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor by carcinomas in a dog and a cat with paraneoplastic leukocytosis

Journal of Veterinary Internal Medicine
L C SharkeyC Steinmeyer

Abstract

A dog with a pulmonary papillary carcinoma and a cat with a dermal tubular adenocarcinoma had profound paraneoplastic neutrophilic leukocytosis with no clinically detectable inflammatory foci. To investigate the mechanism of the leukocytosis, oligonucleotide primers were designed from the cDNA sequences of granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) of dogs. Reverse transcription polymerase chain reaction was performed on tumor tissues, and specific amplification of G-CSF and GM-CSF was obtained with the tumor RNA in the dog. The tumor RNA in the cat demonstrated specific amplification of G-CSF but not GM-CSF. These findings are consistent with the production of G-CSF and/or GM-CSF by neoplasms as a mechanism for paraneoplastic leukocytosis in small animals.

References

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Citations

Nov 18, 2004·Journal of Feline Medicine and Surgery·Robert S DoleMichael R Lappin
Nov 10, 2000·The Journal of Small Animal Practice·C M KnottenbeltM L Chandler
Feb 5, 2011·Veterinary Clinical Pathology·Claudio PetterinoAlessandra Ratto
Oct 12, 2015·JFMS Open Reports·Paulo C JarkAndrigo B De Nardi
May 25, 2002·Veterinary Clinical Pathology·Jacqueline M. TarrantPeter Farrell
Jun 19, 2002·Veterinary Clinical Pathology·Laura Boone, MaryAnn Radlinsky

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