PMID: 16615857Apr 18, 2006Paper

Production of heat shock proteins, cytokines, and nitric oxide in toxic stress

Biochemistry. Biokhimii︠a︡
E G NovoselovaE E Fesenko

Abstract

Expression of heat shock proteins Hsp27, Hsp90, and Hsp70 and production of tumor necrosis factors (TNF-alpha, TNF-beta), interferon-gamma (IFN-gamma), interleukin-2, -3, -6, and nitric oxide (NO) were studied under conditions of acute and chronic intoxication of animals with lipopolysaccharides. Injection of endotoxin increased expression of heat shock proteins Hsp70 and Hsp90-alpha in mouse cells. Acute toxic stress also provoked a sharp increase in the production of TNF-alpha, TNF-beta, and NO in mouse cells. The production of other cytokines (interleukins and IFN-gamma) was changed insignificantly. In the model of chronic toxic stress, changes in the production of Hsp70, Hsp90, TNF, and NO were followed during 11 days after the beginning of the toxin injections. The expression of Hsp70 and Hsp90 in acute stress was significantly higher than at the final stage of the chronic exposure. The changes in the TNF and NO productions, on one hand, and the production of heat shock proteins, on the other hand, were synchronous. The findings indicate that repeated injections of increasing endotoxin doses result in a decreased ability of the body cells to respond to stress by overproduction of heat shock proteins, TNF, and NO.

References

Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·L J Wysocki, V L Sato
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Aug 21, 1995·FEBS Letters· Malyshev IYuA F Vanin
May 21, 1999·Science·J A HoffmannR A Ezekowitz
Dec 28, 1999·Respirology : Official Journal of the Asian Pacific Society of Respirology·Y KohW D Kim
Jul 27, 2001·The Journal of Cell Biology·J C YoungF U Hartl
Mar 27, 2002·Nature Reviews. Immunology·Pramod Srivastava
Jul 10, 2004·Journal of Gastroenterology and Hepatology·Ken-Ichiro MikamiSumio Watanabe
Jul 15, 2004·Journal of Cell Science·Vanessa ChigançasCarlos Frederico Martins Menck
Nov 17, 2004·Cell Stress & Chaperones·Elena Yu KomarovaIrina V Guzhova

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Citations

Jul 1, 1979·Meditsinskaia tekhnika·N I VarichV L Naĭdin
Jul 28, 2012·Cell Stress & Chaperones·Natalia BobkovaMichael Evgen'ev
Jul 20, 2010·Biochemistry. Biokhimii︠a︡·O V GlushkovaE G Novoselova
Sep 6, 2008·Izvestiia Akademii nauk. Seriia biologicheskaia·E G NovoselovaE E Fesenko
Jun 12, 2010·Expert Opinion on Therapeutic Targets·Sergey M Lunin, Elena G Novoselova
May 26, 2009·European Journal of Pharmacology·Elena G NovoselovaEvgeny E Fesenko
Sep 4, 2015·Biological Trace Element Research·Kexin ZhangMingwei Xing

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