PMID: 39891Aug 1, 1979

Production of heat-stable, methanol-soluble enterotoxin by Yersinia enterocolitica

Infection and Immunity
J M BoyceH L DuPont

Abstract

Seven isolates of Yersinia enterocolitica serotype 0:8, recovered during an outbreak of gastrointestinal illness, were examined for enterotoxin production. All seven strains were enterotoxigenic in the suckling mouse model, and three of five isolates tested produced keratoconjunctivitis in the guinea pig eye model (Sereny test). Enterotoxin was detected in broth supernatant fluid after 12 h of incubation at 25 degrees C. The toxin was not inactivated by exposure to 121 degrees C for 30 min or by storage at 4 or -40 degrees C for at least 5 months. The enterotoxin was also acid stable and methanol soluble. Methanol extraction did not affect its heat stability or enterotoxic activity in suckling mice. These physical characteristics plus limited ultrafiltration studies suggest that the enterotoxin is a low-molecular-weight substance. Y. enterocolitica enterotoxin resembles Escherichia coli heat-stable enterotoxin in heat and pH stability, methanol solubility, and enterotoxic activity in suckling mice. However, its role in the pathogenesis of human diarrhea has not been established.

References

Feb 15, 2002·Journal of Bacteriology·Briana M Young, Glenn M Young
Apr 1, 1982·The Journal of Applied Bacteriology·B SwaminathanI J Mehlman
Jan 1, 1980·Microbiology and Immunology·K OkamotoS Yoshii
Apr 1, 1989·The Journal of Applied Bacteriology·S K MeurS K Srivastava
Jan 1, 1983·Transactions of the Royal Society of Tropical Medicine and Hygiene·M Lopez-Brea, M L Jimenez
Jul 1, 1990·The Journal of Applied Bacteriology·S Toora, G Singh

Related Concepts

Pathogenic Aspects
Pathogenesis
Cavia
Toxin
Bacterial Toxins
Sodium Methoxide
Yersinia enterocolitica antigen
Yersinia <bacteria>
Yersinia Infections
Soluble

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Related Papers

Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology
J BockemühlS Aleksic
© 2020 Meta ULC. All rights reserved