PMID: 8592081Jan 1, 1996Paper

Production of heparin-binding epidermal growth factor-like growth factor (HB-EGF) at sites of thermal injury in pediatric patients

The Journal of Investigative Dermatology
D W McCarthyG E Besner

Abstract

Fluids that accumulate at wound sites may be an important reservoir of growth factors that promote the normal wound healing response. The presence of heparin-binding growth factors was studied in burn wound fluid (BWF) from 45 pediatric patients who had sustained partial thickness burns. One of the growth factors present was similar to platelet-derived growth factor (PDGF) based on its heparin affinity, inhibition of bioactivity by a PDGF antiserum, and detection in a PDGF-AB enzyme-linked immunosorbent assay. A second growth factor was identified as heparin-binding epidermal growth factor-like growth factor (HB-EGF) based on its heparin affinity, competition with 125I-labeled epidermal growth factor (EGF) for EGF receptor binding, and recognition in biological assays and Western blots by two HB-EGF antisera. Amino acid sequence analysis of one form of this second growth factor verified its identity as an N-terminally truncated form of HB-EGF. Immunohistochemical analysis of partial thickness burns demonstrated the presence of HB-EGF in the advancing epithelial margin, islands of regenerating epithelium within the burn wound, and in the duct and proximal tubules of eccrine sweat glands. HB-EGF in the surface epithelium of burn ...Continue Reading

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Citations

Mar 8, 2002·The Journal of Burn Care & Rehabilitation·Randolph K CribbsGail E Besner
Jan 18, 2005·World Journal of Surgery·Bishara S AtiyehShady N Hayek
Mar 12, 2005·American Journal of Physiology. Cell Physiology·Naoko Kanda, Shinichi Watanabe
Jul 25, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Shin-Chen PanHaw-Yen Chiu
May 5, 1999·American Journal of Respiratory Cell and Molecular Biology·R PolosaD E Davies
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·S T HolgateD Davies
Jul 5, 2003·Physiological Reviews·Sabine Werner, Richard Grose
Jun 22, 1999·AORN Journal·D D Rose, E B Jordan
Sep 24, 2008·International Wound Journal·Ramin Mostofizadeh Farahani, Luisa A DiPietro
Oct 4, 2014·The Indian Journal of Surgery·T S Venkatachalapathy
Jun 19, 2003·The Journal of Trauma·Nicholas N NissenLuisa A DiPietro
Sep 2, 2004·British Journal of Cancer·T HigenbottamY Fujita
Jan 16, 2014·The Indian Journal of Surgery·T S VenkatachalapathyM J Saliba
Mar 13, 2010·The Journal of Pathology·Gemma M MulderHarry van Goor
Jul 28, 2016·Cell and Tissue Research·Rivka C StoneMarjana Tomic-Canic
Jun 17, 2008·The American Journal of Pathology·Marlon R SchneiderEckhard Wolf
Jun 1, 2005·Journal of Cell Science·Yuji ShirakataKoji Hashimoto
Dec 12, 2000·The Journal of Allergy and Clinical Immunology·R PolosaD E Davies
May 15, 2001·Biochemical and Biophysical Research Communications·M HirataE Mekada
Aug 26, 2000·Cytokine & Growth Factor Reviews·R Iwamoto, E Mekada
Jan 13, 1998·Biochimica Et Biophysica Acta·G Raab, M Klagsbrun
Aug 2, 2001·Journal of Pediatric Surgery·M P MichalskyG E Besner
Feb 7, 2004·Seminars in Pediatric Surgery·Osama N El-Assal, Gail E Besner
Mar 11, 2006·Burns : Journal of the International Society for Burn Injuries·Ceren AlemdaroğluDeniz Erdoğan
Nov 25, 2006·The Journal of Investigative Dermatology·Martina I OkwuezeLillian B Nanney
Aug 9, 2005·Seminars in Pediatric Surgery·Jiexiong FengGail E Besner

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