Production of human antithyroglobulin in vitro, IV. Specific stimulation by antigen

The Journal of Clinical Endocrinology and Metabolism
G N Beall

Abstract

Peripheral blood lymphocytes from patients whose serum contains antithyroglobulin are capable of producing antithyroglobulin (anti-Tg) in vitro when stimulated with insolubilized Tg and suboptimal amounts of pokeweed mitogen. Antigen stimulation of anti-Tg production was demonstrated in 6 of 10 experiments in which a 1:10,000 dilution of pokeweed mitogen was also included. Larger concentrations of antigen appeared to inhibit anti-Tg synthesis. Regulation of antigen-stimulated anti-Tg production by the patients' T cells was not different from regulation by the T cells of normal subjects. Both T help and T suppression of antigen-induced antibody synthesis was demonstrated with patients' T cells. These experiments continue to provide evidence that production of the autoantibody anti-Tg is related to an abnormality of B cells.

Citations

Jan 3, 1983·Life Sciences·E De Bernardo, T F Davies
Jan 1, 1983·Molecular Aspects of Medicine·N R FaridJ C Bear
Dec 9, 1982·The New England Journal of Medicine·C R StrakoschR Volpé
Oct 1, 1983·Journal of Clinical Immunology·E De Bernardo, T F Davies
Jan 1, 1982·Magnetic Resonance Imaging·P T Beall
May 1, 1984·Allergy·K BechH Nielsen
Jan 1, 1988·Critical Reviews in Clinical Laboratory Sciences·S D FlynnS T Bigos
Feb 1, 1984·Journal of Endocrinological Investigation·W PruzanskiR Volpé

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