Production of human-inducible nitric oxide synthase in radicular cysts

Journal of Endodontics
O TakeichiT Saito

Abstract

To examine if nitric oxide (NO) is produced in radicular cysts, NO synthase (NOS) production was analyzed. Periapical tissues were removed from patients at the time of endodontic surgery. Frozen tissue sections were histologically evaluated with hematoxylin-eosin staining. Production of human-inducible NOS (iNOS) in apical cysts was then immunohistochemically examined. Immunoreactive human iNOS was widely distributed in epithelial cells, endothelial cells, fibroblasts, macrophages, or polymorphonuclear leukocytes. Remarkably, iNOS-positive cells were significantly present around blood vessels, and cells residing apart from the blood vessels showed weak or no iNOS production, suggesting that only cells around blood vessels could be stimulated for iNOS synthesis. These data demonstrated the possibility that several, but not all, cells could be stimulated to synthesize iNOS in inflamed tissues. In the presence of iNOS, NO can be produced spontaneously in periapical lesions and may play a crucial role in the regulation of chronic infection.

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Citations

Aug 26, 1998·Clinical and Experimental Immunology·K D KrönckeV Kolb-Bachofen
Mar 7, 2001·Antioxidants & Redox Signaling·K D KrönckeV Kolb-Bachofen
May 7, 2002·Journal of Periodontology·Farzaneh DaghighJoseph H Bee
Jun 2, 2009·Journal of Endodontics·Fernanda Geraldes PappenRenato de Toledo Leonardo
Mar 6, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Nobuyuki KawashimaHideaki Suda
Dec 2, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Kyung-San MinEun-Cheol Kim
Apr 30, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Kyung-San MinEun-Cheol Kim
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Sep 1, 2005·Journal of Applied Oral Science : Revista FOB·Celso Emanoel de Souza QueirozWelington Dinelli
Nov 8, 2007·Digestive Diseases and Sciences·Nurullah KeklikogluSevtap Akinci
Sep 11, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Takahiro SuzukiKatsutoshi Motegi
Jan 5, 2002·Journal of Endodontics·H ShimauchiH Okada

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