Production of human tumor necrosis factor alpha, interleukin-6, and interleukin-10 is induced by lactic acid bacteria.

Infection and Immunity
M MiettinenK Varkila

Abstract

To investigate the role of cytokines in interactions between lactic acid bacteria and the immune system, we measured production of tumor necrosis factor alpha, interleukin-6 (IL-6), and IL-10 from human peripheral blood mononuclear cells after stimulation with live or glutaraldehyde-fixed bacteria. Production of tumor necrosis factor alpha, IL-6, and, in some cases, IL-10 was induced in amounts even greater than those obtained with lipopolysaccharide as a stimulant. Our results suggest that lactic acid bacteria can stimulate nonspecific immunity.

References

Dec 1, 1991·Infection and Immunity·S BhakdiW Fischer
Dec 1, 1972·Bacteriological Reviews·K H Schleifer, O Kandler
May 14, 1969·Journal of Molecular Biology·H W Boyer, D Roulland-Dussoix
Apr 1, 1995·Journal of Pediatric Gastroenterology and Nutrition·H MajamaaT Vesikari
Nov 1, 1994·FEMS Immunology and Medical Microbiology·H Link-AmsterJ M Aeschlimann
Oct 1, 1994·The Journal of Applied Bacteriology·G R Gibson, X Wang
Aug 1, 1994·Clinical Immunology and Immunopathology·L BreuningerD M Murasko
Jan 1, 1993·Annual Review of Cell Biology·K J Tracey, A Cerami
Jun 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A Lidbeck, C E Nord

❮ Previous
Next ❯

Citations

Feb 19, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L PeltoS Salminen
Dec 21, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T PessiE Isolauri
Jul 6, 2001·Scandinavian Journal of Immunology·X ZhangP Toivanen
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hanne R ChristensenJames J Pestka
Jun 5, 2002·Clinical Reviews in Allergy & Immunology·Andrea T BorchersM Eric Gershwin
Mar 15, 2003·Journal of Food Protection·Timothy D WallaceJulia M Green-Johnson
Oct 30, 2003·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jeffrey I MechanickUNKNOWN American Association of Clinical Endocrinologists
Jan 25, 2005·Infection and Immunity·Martín A HumenPablo F Pérez
May 6, 2005·Paediatric Drugs·Hania Szajewska, Jacek Z Mrukowicz
May 19, 2006·Journal of Pediatric Gastroenterology and Nutrition·Hania SzajewskaStefano Guandalini
Mar 15, 2006·World Journal of Gastroenterology : WJG·Mária FiglerSándor Szakály
Mar 16, 2007·Clinical and Vaccine Immunology : CVI·C Maldonado GaldeanoG Perdigón
Jan 10, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Patricia L Hibberd, Lisa Davidson
May 18, 2011·International Archives of Allergy and Immunology·Chia-Yang LiShih-Hua Fang
Aug 13, 2011·Beneficial Microbes·M Meijerink, J M Wells
May 10, 2013·Archives of Pharmacal Research·Do Kyung LeeNam Joo Ha
Mar 13, 2014·PloS One·Alexandria N ArdissoneJosef Neu
Dec 1, 2011·Probiotics and Antimicrobial Proteins·Umesh Kr ShandilyaV K Kansal
Nov 11, 1999·Clinical and Experimental Immunology·T ChenP Toivanen
Jun 11, 2002·Annual Review of Nutrition·Jonathan E Teitelbaum, W Allan Walker
Nov 18, 2000·Infection and Immunity·C L HahnJ G Tew
Nov 22, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L E M NiersM O Hoekstra
Apr 29, 2004·BMC Gastroenterology·Michael SchultzHeiko C Rath
Sep 15, 2004·FEMS Immunology and Medical Microbiology·Martin L CrossLinley M Fray
Mar 8, 2008·Expert Review of Vaccines·Mansour MohamadzadehTodd R Klaenhammer
Aug 19, 2007·Journal of Dairy Science·T M CoganZ Ustunol
Jul 20, 2010·International Journal of Molecular Sciences·Lay-Gaik Ooi, Min-Tze Liong
Oct 30, 2007·Journal of Leukocyte Biology·Ville Veckman, Ilkka Julkunen
Jan 19, 2010·The Journal of Dairy Research·Angela TellezMansel W Griffiths
Apr 7, 2006·Expert Review of Anti-infective Therapy·Shira Doron, Sherwood L Gorbach

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.