PMID: 2507743Nov 1, 1989Paper

Production of hyperalgesic prostaglandins by sympathetic postganglionic neurons

Journal of Neurochemistry
R GonzalesJ D Levine

Abstract

Prostaglandin E2 and prostacyclin (prostaglandin I2) produce hyperalgesia in animals and humans. Because there is evidence that prostaglandins contribute to pain maintained by sympathetic nervous system activity, we evaluated whether sympathetic postganglionic neurons synthesize these hyperalgesic prostaglandins, and whether production of prostaglandins by these neurons can contribute to sensitization of primary afferent nociceptors. Intradermal injection of arachidonic acid but not linoleic acid, in the rat hindpaw, produces a decrease in mechanical nociceptive threshold. This hyperalgesic effect is prevented by indomethacin, an inhibitor of prostaglandin synthesis or by prior surgical removal of the lumbar sympathetic chain. To test the hypothesis that sympathetic postganglionic neurons are the source of prostaglandins, we measured production of prostaglandin E2 and 6-keto-prostaglandin F1 alpha (the stable metabolite of prostacyclin) by homogenates of adult rat sympathetic postganglionic neurons from superior cervical ganglia. These homogenates produced significant amounts of prostaglandin E2 and 6-keto-prostaglandin F1 alpha, and most of this production is eliminated by neonatal administration of 6-hydroxydopamine which sel...Continue Reading

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Citations

Apr 22, 1996·European Journal of Pharmacology·H CambridgeS D Brain
Jun 1, 1995·Journal of the Neurological Sciences·R Levi-MontalciniA Leon
Nov 28, 1997·Prostaglandins·W E KaufmannP F Worley
Nov 14, 2012·Nature Reviews. Rheumatology·Georg Pongratz, Rainer H Straub
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P G GreenJ D Levine
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·J NardoneP G Hogan
Jul 6, 2005·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Christian L Baum, Christopher J Arpey
Jan 16, 2014·Autonomic Neuroscience : Basic & Clinical·Hans-Georg Schaible, Rainer H Straub
Sep 23, 2014·Prostaglandins & Other Lipid Mediators·Karen WagnerBruce D Hammock
Feb 24, 2016·Expert Review of Neurotherapeutics·Brian Edwin Cairns
Jun 26, 2007·European Journal of Pain : EJP·Peter D Drummond
Jan 20, 2007·European Journal of Pain : EJP·Jörn SchattschneiderRalf Baron
Feb 12, 1990·Brain Research·C MiaskowskiJ D Levine
Jun 28, 2015·BMC Complementary and Alternative Medicine·Simon EgliLorenz Fischer
Oct 1, 1993·Pain·Hans-Georg Schaible, Blair D Grubb
Jun 26, 1999·Microscopy Research and Technique·L M MendellB M Davis
Sep 27, 2018·Trends in Hearing·Arnaud J NoreñaNicolas Charpentier
Mar 24, 2015·Obstetrics & Gynecology Science·Ye Jin ChoiJae Whoan Koh
Jun 10, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S DurandP Abraham
Feb 12, 2021·Cellular Signalling·Rebecca SohnZsuzsa Jenei-Lanzl

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