Production of IL-6 by T cells from the femoral head of patients with rapidly destructive coxopathy (RDC)

Clinical and Experimental Immunology
M TamaiK Itoh

Abstract

RDC is a syndrome with unknown etiology that causes rapid destruction of a hip joint. We have investigated the production of osteoclast-activating cytokines (IL-6, IL-1alpha and tumour necrosis factor-alpha (TNF-alpha)), interferon-gamma (IFN-gamma) and IL-8 by T cells in the affected joint. The level of IL-6 produced by the T cell lines (TCL) established from the femoral head was significantly higher than that from patients' or healthy donors' peripheral blood mononuclear cells (PBMC). IL-6 production by the TCL from synovial membrane or from patients' PBMC was also significantly higher than that from healthy donors' PBMC. IL-1alpha production by the TCL from the femoral head was significantly higher than any of the other groups when all the TCL were used for the analysis. TNF-alpha production was highest in the TCL from patients' PBMC. The levels of IFN-gamma or IL-8 were not significantly different among these four groups. The plasma levels of all these cytokines except for IFN-gamma, that was rather lower, in RDC patients were not significantly different from those in osteoarthrosis or trauma patients, or healthy donors. These results suggest that T cells at the affected femoral head, and also synovial membrane to some exte...Continue Reading

References

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Citations

Dec 30, 1998·Calcified Tissue International·L Rifas
Oct 31, 2007·Journal of Bone and Mineral Metabolism·Kenji OgawaTakao Hotokebuchi
Jun 8, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yusuke KuboYasuharu Nakashima
Jan 15, 2008·Journal of Orthopaedic Surgery and Research·Sameer BatraA K Sinha
May 6, 2005·Journal of Orthopaedic Surgery·T YamakawaA Uchida
Oct 19, 2013·Rheumatology·Hirohito AbeNobuhiko Sugano

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