PMID: 6171873Jan 1, 1981Paper

Production of immune interferon (type II) in cocultures of mouse peritoneal macrophages and syngeneic tumour cells

Scandinavian Journal of Immunology
R OlstadR Seljelid

Abstract

Mouse peritoneal macrophages were activated by coculture with syngeneic methylcholanthrene-induced sarcoma cells [7], which grow as an ascites tumour in C3D2 mice [3]. During 4-5 days of cocultivation tumour cells progressively died, leaving highly activated macrophages. Cell-free supernatant harvested from the cultures contained larger amounts of interferon than either macrophages or tumour cells cultivated alone. Peak activity of interferon occurred on day 2. Non-adherent cells cultivated together with tumour cells did not produce interferon. Removal of all non-adherent cells from macrophage cultures and host cells from tumour cell suspension did not abolish interferon production. The macrophages thus seem to be the interferon-producing cells, but the possibility that the very few remaining lymphocytes may cooperate with the macrophages in interferon production cannot be totally ruled out. The interferon produced could not be inactivated by antibodies against virus-induced interferon and was destroyed by treatment at pH 2, indicating that the interferon was not of the alpha or beta type.

References

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Oct 1, 1977·European Journal of Immunology·C Neumann, C Sorg
Oct 27, 1978·Biochimica Et Biophysica Acta·I Gresser, M G Tovey
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Citations

Oct 1, 1998·Cytokine & Growth Factor Reviews·S Gessani, F Belardelli
Sep 28, 2001·Trends in Immunology·D M FruchtS Koyasu
May 1, 1994·The Journal of Experimental Medicine·P Di MarzioS Gessani
Sep 1, 1993·American Journal of Reproductive Immunology : AJRI·N A KleinR S Schenken
Sep 30, 1994·Annals of the New York Academy of Sciences·N A KleinR S Schenken
Dec 1, 1983·Annals of the Rheumatic Diseases·M DeGréO Clarke-Jenssen
Nov 1, 1982·Scandinavian Journal of Immunology·R OlstadR Seljelid
May 16, 2006·Trends in Immunology·Christian Bogdan, Ulrike Schleicher
Jun 22, 2016·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Alec FalkenhamJean Francois Legare
Nov 15, 1983·International Journal of Cancer. Journal International Du Cancer·A GrönbergG Klein
Jun 13, 2020·Journal of Leukocyte Biology·Soraya Mezouar, Jean-Louis Mege
Jan 1, 1994·European Journal of Haematology·R Seljelid, L T Busund

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