Production of inhibin A and inhibin B in human ovarian sex cord stromal tumors

American Journal of Obstetrics and Gynecology
K YamashitaR Nakano

Abstract

Our purpose was to examine the cellular localization of inhibin subunits and messenger ribonucleic acid expressions for the inhibin subunits and the serum levels of inhibin A and inhibin B in human ovarian sex cord stromal tumors. We examined the immunohistochemical localization of the inhibin subunits and the expression of the corresponding messenger ribonucleic acids by Northern blot analysis in a granulosa cell tumor and a Sertoli-Leydig cell tumor. We also measured serum concentrations of dimeric inhibin A and inhibin B by two-site enzyme-linked immunosorbent assay. Immunostaining specific for the inhibin alpha, betaA, and betaB subunits was observed in the granulosa cell tumor. In the Sertoli-Leydig cell tumor we observed immunostaining specific for the alpha subunit in Leydig tumor cells and that specific for the betaA subunit in Sertoli tumor cells and that specific for the betaB subunit in both tumor cells. Northern blot analysis revealed the presence of messenger ribonucleic acids for the alpha, betaA, and betaB subunits in the granulosa cell tumor and the Sertoli-Leydig cell tumor. The serum levels of dimeric inhibin A and inhibin B in patients were elevated preoperatively and decreased progressively after surgery. Ou...Continue Reading

References

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Citations

Oct 20, 2007·Cancer Treatment Reviews·D PectasidesA Psyrri
Feb 13, 1999·American Journal of Obstetrics and Gynecology·K YamashitaR Nakano
Sep 26, 2008·Integrative Cancer Therapies·Georgios V KoukourakisAthanasios Gouliamos
Feb 24, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·W G McCluggage
May 12, 2001·Pathology Oncology Research : POR·F KabukcuogluR Ilhan
Jan 30, 2018·Clinical and Experimental Reproductive Medicine·Braira WahidAleena Sumrin
Aug 27, 2019·Reproduction in Domestic Animals = Zuchthygiene·Hossam El-Sheikh AliTakeshi Osawa
Jan 15, 2002·The Journal of Clinical Endocrinology and Metabolism·Catherine S ChoongHenry G Burger
Dec 12, 2001·Endocrine Reviews·G P RisbridgerD M Robertson
Jun 5, 2003·Acta Obstetricia Et Gynecologica Scandinavica·Kimmo K VihkoPentti Tuohimaa
Mar 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan Tinsley Schumer, Stephen A Cannistra
Jan 24, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Angiolo GadducciAndrea Riccardo Genazzani

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