Production of interferons and lymphokines in leukocyte cultures of patients with schizophrenia

Schizophrenia Research
M HornbergH Kirchner

Abstract

Recently, several lines of evidence have suggested the possible of immunological dysfunction in the pathogenesis of schizophrenia. We therefore investigated the ability to produce interferons and lymphokines in response to mitogenic or viral stimulation in a whole blood assay of 37 schizophrenic patients (DSM-III-R) and of 42 healthy blood donors. Phytohaemagglutinin (PHA) was used for the induction of interleukin-2 (IL-2), interferon gamma (INF gamma), interleukin-6 (IL-6) and the soluble interleukin-2 receptor (sIL-2R) and Newcastle Disease Virus (NDV) for the induction of interferon alpha 2 (INF alpha 2). All lymphokines and, in addition, the sIL-2R in the sera were determined by ELISA technique. The psychopathological status of the patients was assessed by psychiatrists according to internationally accepted standards. The patient group showed a trend to lower levels of the interferons alpha 2 and gamma and a significant decrease of IL-2 production. The sIL-2R levels were significantly increased in the sera of schizophrenic patients. The latter increase was associated with a poor assessment of prognosis (Strauss and Carpenter). This association appears to be of interest. However, its significance is not understood, since lon...Continue Reading

References

Jan 1, 1990·Journal of Clinical Laboratory Analysis·M Biondi, G D Kotzalidis
Mar 1, 1989·Archives of General Psychiatry·M H RapaportS M Paul
Mar 1, 1989·Archives of General Psychiatry·R Ganguli, B S Rabin
Aug 1, 1989·Biological Psychiatry·R GanguliS H Belle
Jan 1, 1988·Schizophrenia Bulletin·C B PertM A Markwell
Nov 1, 1988·Acta Psychiatrica Scandinavica·A NiiranenK Cantell
Sep 1, 1987·Annals of Internal Medicine·K D DenicoffS A Rosenberg
Oct 9, 1986·The New England Journal of Medicine·W A KayeG S Eisenbarth
Nov 1, 1986·The British Journal of Psychiatry : the Journal of Mental Science·E Hare
May 1, 1968·The Journal of General Virology·E De Maeyer, J De Maeyer-Guignard
Jan 22, 1983·Lancet·T J Crow
Jan 1, 1982·Journal of Immunological Methods·H KirchnerW Digel
Jun 1, 1982·The Journal of Clinical Investigation·J Alcocer-Varela, D Alarcón-Segovia
Aug 1, 1993·Mechanisms of Ageing and Development·J SindermannH Kirchner

❮ Previous
Next ❯

Citations

Jan 1, 1996·European Archives of Psychiatry and Clinical Neuroscience·I WilkeH Kirchner
Jan 1, 1997·European Archives of Psychiatry and Clinical Neuroscience·N MüllerM Ackenheil
Jun 25, 2008·European Archives of Psychiatry and Clinical Neuroscience·Yuichiro WatanabeToshiyuki Someya
Apr 15, 2004·Journal of Neuroimmunology·Hsing-Cheng LiuSy-Jye Leu
Dec 15, 1996·Biological Psychiatry·M RothermundtH Kirchner
Feb 21, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Carlo L CazzulloMario Clerici
Aug 22, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Martin SchaeferKlaus Lieb
Jul 1, 1997·Progress in Neuro-psychopharmacology & Biological Psychiatry·M H RapaportJ B Lohr
Apr 9, 1998·Progress in Neuro-psychopharmacology & Biological Psychiatry·N Müller, M Ackenheil
Oct 28, 1998·Progress in Neuro-psychopharmacology & Biological Psychiatry·C L CazzulloM Clerici
Mar 30, 2001·Schizophrenia Research·C L CazzulloM Clerici
Jan 1, 1997·European Psychiatry : the Journal of the Association of European Psychiatrists·N MüllerM Ackenheil
Sep 18, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mark H Rapaport, Catherine Bresee
Nov 27, 2007·Neuropsychobiology·Kyeong-Sae Na, Yong-Ku Kim
Jul 1, 1999·Biological Psychiatry·S Y TsaiS J Leu
Feb 28, 2003·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·J KowalskiZ S Herman
Oct 16, 2012·Biological Psychiatry·Brian J MillerAndrew Mellor
Jun 9, 2009·Journal of Reproductive Immunology·Lorenza DíazFernando Larrea
Apr 4, 2006·Brain, Behavior, and Immunity·Lukasz DrzyzgaZbigniew S Herman
Jul 23, 2004·Expert Opinion on Investigational Drugs·Norbert MüllerMichael Riedel
Jan 10, 2002·Brain, Behavior, and Immunity·M J SchwarzM Ackenheil
Dec 3, 2014·Psychiatry Research·Yousri El KissiJalel Boukadida
Mar 25, 2016·Indian Journal of Psychological Medicine·Maju Mathew Koola
Feb 28, 2003·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·N MüllerM J Schwarz
Aug 9, 2002·The Journal of International Medical Research·S EbrinçM Cetin
Jul 7, 2005·CNS Spectrums·M H Rapaport, K K Delrahim
Mar 28, 2001·Annals of the New York Academy of Sciences·N MüllerM J Schwarz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.