Production of interleukin-10 in asthmatic children after Beta-1-3-glucan

Allergologia et immunopathologia
E SarinhoJ A Rizzo

Abstract

Beta-1-3 Glucan is a polysaccharide extracted from Saccharomyces cerevisiae with a possible immunomodulating action that may have a favourable action on asthma symptoms and other allergic diseases. An experimental study carried out using a murine respiratory model detected a decrease in pulmonary tissue eosinophilia, as well as an increase in Interleukin-10 (IL-10) after glucan use. This open, exploratory study with blind outcome evaluation included asthmatic children between 6 and 12 years of age with mild to moderate persistent asthma and inadequate disease control (rescue medication needed more than twice a week) in spite of inhaled budesonide 400 microg/day. After a four week run-in period, subcutaneous Beta-1-3-glucan injections were given weekly for the first four weeks and then every two weeks for the last four weeks. IL-10 levels, measured by the immunoenzymatic method (ELISA), were compared before and after glucan administration. Twenty patients (14 male and 6 female) were included. Mean IL-10 levels were 6.4 pg/ml and 11.3 pg/ml before and after glucan, respectively (p = 0.02). There was also a reduction of asthmatic symptoms score at the end of study. This is the first study which shows that subcutaneous particulate ...Continue Reading

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Citations

Dec 14, 2011·Clinical and Experimental Pharmacology & Physiology·C O TorelloM L S Queiroz
Dec 21, 2012·Allergologia et immunopathologia·Milos JesenakJuraj Majtan
Oct 19, 2010·International Immunopharmacology·Cristiane O TorelloMary L S Queiroz
Sep 6, 2017·International Journal of Molecular Sciences·Khawaja Muhammad Imran Bashir, Jae-Suk Choi
Apr 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vaclav VetvickaJosef Richter
Jan 27, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·X-L TangC-H Yuan

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