Production of interleukin (IL)-33 in the lungs during multiple antigen challenge-induced airway inflammation in mice, and its modulation by a glucocorticoid

European Journal of Pharmacology
Takeshi NabeShin Yoshino

Abstract

Although interleukin (IL)-33 is a candidate aggravator of asthma, the cellular sources of IL-33 in the lungs during the progression of antigen-induced airway inflammation remain unclear. Furthermore, it has not been determined whether the antigen-induced production of IL-33 can be pharmacologically modulated in vivo. In this study, we examined the production of IL-33 in the lungs of sensitized mice during multiple intratracheal challenges with the antigen, ovalbumin. The 1st challenge clearly induced the IL-33 production in the lungs, and it was enhanced by the 2nd-4th challenges. IL-33 mRNA transcription was also induced after these challenges. An immunohistochemical analysis revealed that the cellular sources of IL-33 after the 1st challenge were mainly bronchial epithelial cells, while those after the 3rd challenge were not only the epithelial cells, but also inflammatory cells that infiltrated the lungs. Flow cytometric analyses indicated that approximately 20% and 10% of the IL-33-producing cells in the lungs were M2 macrophages and conventional dendritic cells, respectively. A systemic treatment with dexamethasone before the 1st challenge potently suppressed the IL-33 production. When dexamethasone was administered before...Continue Reading

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Citations

Jul 14, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mingyuan HanMarc B Hershenson
Apr 1, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Charu RajputMarc B Hershenson
May 19, 2018·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Carina G UasufElisabetta Pace
Nov 20, 2019·Probiotics and Antimicrobial Proteins·Yang WangJinshan Zhao
Dec 7, 2016·Pflügers Archiv : European journal of physiology·Oliver H Wittekindt
Feb 9, 2017·Military Medical Research·Hui XuTimothy R Billiar
Dec 14, 2018·Oncoimmunology·Alfredo Perales-PuchaltDavid B Weiner
Sep 12, 2019·Pediatric Allergy, Immunology, and Pulmonology·Ufuk CakirCigdem Yucel
Jan 26, 2021·Frontiers in Immunology·Elise G LiuStephanie C Eisenbarth
Oct 27, 2017·Translational Research : the Journal of Laboratory and Clinical Medicine·Arjun SaradnaPeisong Gao

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