PMID: 44413Jan 1, 1979

Production of L-asparaginase by Streptomyces karnatakensis and Streptomyces venezuelae

Zentralblatt Für Bakteriologie, Parasitenkunde, Infektionskrankheiten Und Hygiene. Zweite Naturwissenschaftliche Abteilung: Mikrobiologie Der Landwirtschaft Der Technologie Und Des Umweltschutzes
S A Mostafa

Abstract

Production of L-asparaginase by two soil isolates, identified as S. karnatakensis and S. venezuelae, was investigated under different environmental and nutritional conditions. The presence of carbon sources, other than starch, in the growth medium or amino acids, other than L-asparagine-inhibited the enzyme biosynthesis. L-aspartic inhibited growth and enzyme production, due to a feedback mechanism, and/or lowering the pH value. Both organisms were stimulated to produce more enzyme with increasing concentrations of starch and L-asparagine, however, the optimum starch and L-asparagine concentration depended on the tolerance of the organism to low and high pH, respectively. Aeration stimulated growth, but not enzyme production, and both organisms produced more enzyme in static cultures than in shaken cultures.

References

Dec 1, 1971·Journal of General Microbiology·H E WadeB W Phillips

Citations

Sep 1, 2008·Indian Journal of Microbiology·K J P NarayanaM Vijayalakshmi
Mar 13, 2014·TheScientificWorldJournal·Neelima DeshpandeManasi Agashe
Jan 19, 2020·Biotechnology and Applied Biochemistry·Subhash ChandGirish Sharma
Aug 31, 2000·Applied and Environmental Microbiology·N J BurroughsE M Wellington

Related Concepts

Asparaginase medac
Asparagine
Hydrogen-Ion Concentration
Soil Microbiology
Keoflo
Molecular Stereochemistry
Streptomyces

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