PMID: 7512880Aug 1, 1993Paper

Production of multiple cytokines by cultured human melanomas

Experimental Dermatology
J L Bennicelli, D Guerry

Abstract

We screened a panel of 8 primary and 21 metastatic melanoma cell lines for constitutive secretion of cytokines. Melanomas expressed bioactivity for TGF-beta (8/25 lines) and IFN (7/12), but not IL-2. Immunoassays detected IL-1 alpha (4/25), IL-1 beta (12/25), IL-6 (13/29), IL-8 (29/29), TGF-beta 2 (5/12) and GM-CSF (11/29), but not IL-3, IL-4, TNF-alpha, or IFN-gamma. There was no preferential association of cytokine production with cells cultured from primary versus metastatic disease, and only IL-8 was produced by all lines tested. These data demonstrate that cultured melanomas produce a variety of cytokines which are potentially capable of influencing tumor growth in vivo.

References

Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J E de Larco, G J Todaro
Jul 1, 1992·Experimental Dermatology·C A ArmstrongJ C Ansel
Mar 29, 1991·Biochemical and Biophysical Research Communications·N BirchallJ Pawelek
Jul 1, 1991·The Journal of Investigative Dermatology·U RodeckM Herlyn
Nov 30, 1990·Biochemical and Biophysical Research Communications·Y MorinagaK Onozaki

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Citations

Nov 1, 1996·Seminars in Surgical Oncology·C L Slingluff
Dec 10, 2002·International Journal of Cancer. Journal International Du Cancer·Helmut SchaiderMeenhard Herlyn
Jun 2, 2007·Cancer Chemotherapy and Pharmacology·Vincent A PollackWilliam J LaRochelle
Sep 7, 2001·Cytokine & Growth Factor Reviews·K Xie
Sep 18, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Q ShiK Xie
May 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·D PagliaR C McKenzie
Feb 7, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Richard C WuLaszlo G Radvanyi
Nov 17, 2007·The Journal of Clinical Investigation·Kimberly B PetermannNorman E Sharpless
Oct 28, 2014·The Journal of Clinical Investigation·Regina LinQi-Jing Li
Jul 23, 2008·Experimental Dermatology·Dan Ilkovitch, Diana M Lopez
May 21, 2010·Experimental Dermatology·Nan-Lin WuChi-Feng Hung
Jul 31, 1998·Hematology/oncology Clinics of North America·R Gutzmer, D Guerry
Jun 29, 2016·Journal of Experimental & Clinical Cancer Research : CR·Laura PaladiniLibero Santarpia
Feb 13, 2016·Journal of Clinical Pathology·George JourPhyu P Aung
Jun 15, 2005·Journal of Cutaneous Pathology·Mahmoud R Hussein
Mar 2, 2016·Melanoma Research·Jennifer NguyenK Taraszka Hastings
Jun 28, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Colleen S CurranPaul J Bertics
Apr 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mojgan Ahmadzadeh, Steven A Rosenberg
Feb 6, 2020·Molecular Medicine Reports·Chuhan FuQinghai Zeng
Mar 30, 1999·International Journal of Cancer. Journal International Du Cancer·S MorettiM Herlyn

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