PMID: 11323107Apr 27, 2001Paper

Production of neuropeptide substance P by synovial fibroblasts from patients with rheumatoid arthritis and osteoarthritis

Neuroscience Letters
H InoueY Koshihara

Abstract

We examined the production of substance P (SP) in synovial fibroblasts derived from patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Immunoreactive SP was observed in non-stimulated RA fibroblasts. The expression of beta-preprotachykinin-A (beta-PPT-A) mRNA was confirmed by reverse transcription-polymerase chain reaction analysis. SP contents in culture medium were increased by treatment of RA fibroblasts with transforming growth factor-beta (TGFbeta) (10 ng/ml). Levels of SP release were elevated at 12 h after TGFbeta stimulation whereas the expression of beta-PPT-A mRNA was enhanced at 3 h. Furthermore, SP production in response to TGFbeta was dose-dependently enhanced by basic fibroblast growth factor (bFGF). OA fibroblasts also significantly released SP in the presence of TGFbeta (10 ng/ml) plus bFGF (50 ng/ml). These results suggest that SP produced by synovial fibroblasts may participate in joint diseases.

References

Jan 1, 1990·Annual Review of Cell Biology·J Massagué
Nov 11, 1989·Lancet·B L KiddD R Blake
Jan 1, 1989·The Journal of Experimental Medicine·R FavaT Pincus
Jan 1, 1996·Annual Review of Immunology·M FeldmannR N Maini
Jan 1, 1996·Rheumatology International·T TanabeC Inagaki
Nov 14, 1997·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·A Hecker-KiaN Ulbrich

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Citations

Jul 2, 2009·Plastic and Reconstructive Surgery·Michael S ChinRei Ogawa
Aug 20, 2014·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Zhi-Ming LiuWei Fang
Sep 18, 2014·Regulatory Peptides·Hiroyuki YamamotoMinoru Hoshino
May 23, 2007·Brain, Behavior, and Immunity·Rainer H Straub
Feb 26, 2008·Scandinavian Journal of Medicine & Science in Sports·U Fredberg, K Stengaard-Pedersen
Apr 30, 2017·International Journal of Molecular Sciences·Susanne Grässel, Dominique Muschter
Apr 15, 2005·American Journal of Physiology. Cell Physiology·Burgess N ChristensenKarin N Westlund
May 2, 2018·Frontiers in Veterinary Science·Olga KrupkovaAntonio Pozzi
Mar 18, 2020·Frontiers in Endocrinology·Fu-Xing-Zi LiLing-Qing Yuan
Jul 25, 2018·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Birgitta Gatenholm, Mats Brittberg
May 6, 2021·Journal of Clinical Medicine·Susanne GrässelHenning Madry

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