Production of passive cutaneous anaphylaxis (PCA) and reversed PCA by rat IgE antibody in the mouse

Experientia
M HaradaM Takeuchi

Abstract

Although IgE antibody is generally characterized as a homocytotropic antibody, it has been well known for some time that mouse IgE antibody causes potent sensitization of rat skin for PCA. The present study clearly shows the reciprocal cross-sensitization of mouse skin with rat IgE molecules. PCA and RPCA were produced by rat IgE antibody in an inbred mouse strain. DS/Shi, though not in C3H/HeShi, C57BL/6JShi and BALB/cCrj strains. Sensitization of DS/Shi mouse skin for PCA with rat IgE antibody was comparable in sensitivity with that of rat skin, but lasted only for a short term in comparison with the long persistence in rat skin.

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Related Concepts

Monoclonal Antibodies
Mice, Inbred BALB C
August Rats
Passive Cutaneous Anaphylaxis
Immune Sera
Mice, Inbred C3H
Immunoglobulin E
Antigens
Mouse Skin
Anaphylaxis

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Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.