Production of proteases type plasminogen activator and their inhibitor in cornea

Biochemical and Biophysical Research Communications
M MirshahiJ P Faure

Abstract

Corneal epithelial cells secrete tissue plasminogen activator (t-PA), urokinase type plasminogen activator (u-PA) and their inhibitor (PAI), whereas these cell types in other tissues are known to secrete only u-PA hitherto. Endothelial cells in the cornea produce mostly u-PA and only small amounts of t-PA and PAI which remain confined in the cellular compartment contrary to the situation in the vascular endothelial cells where they are liberated into the circulation in the order PAI greater than t-PA greater than U-PA. These unique features of activator/inhibitor secretion and production may play an important role in the remodeling of the corneal matrix.

References

Jul 1, 1978·The Journal of Experimental Medicine·A Granelli-Piperno, E Reich
Sep 1, 1979·Experimental Eye Research·L FehrenbacherM A Shuman
Jan 1, 1985·Advances in Cancer Research·K DanøL Skriver
Feb 1, 1988·Experimental Eye Research·K Hayashi, K Sueishi
Sep 1, 1985·Experimental Eye Research·M A Shuman, C H Merkel
Jan 24, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·B WimanM Rånby
Mar 12, 1984·FEBS Letters·P KristensenK Danø

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Citations

May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·F GriscelliH Lu
May 1, 1996·Clinical Rheumatology·A al-Arfaj
Jan 29, 2000·European Journal of Ophthalmology·G Malukiewicz-Wiśniewska, M Kotschy
Jun 1, 1994·Current Eye Research·S S TwiningX Zhou

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