PMID: 2598173Jan 1, 1989

Production of specific macrophage-arming factor precedes cytotoxic T lymphocyte activity in vivo during tumor rejection

Cancer Immunology, Immunotherapy : CII
H F DullensW D Den Otter

Abstract

Recently we published a hypothesis on the immunological events occurring during tumor rejection. One of the implications of this hypothesis is that specific macrophage-arming factor (SMAF) is produced early during the initiation of the immune response, whereas the "classical" cell-mediated immune response components, such as cytotoxic T lymphocytes (CTL), are produced later, that is, during the amplifier-effector phase. In this paper we establish the kinetics of the induction of (a) lymphocytes producing SMAF and (b) CTL. Groups of DBA/2 mice were injected i.p. once, twice or three times with irradiated and/or non-irradiated syngeneic SL2 tumor cells, the injections being given at intervals of 10 days. After each of these injections the production of SMAF and the expression of CTL activity were established. The results showed that in the peritoneal cavity SMAF-producing lymphocytes appeared earlier than cytotoxic lymphocytes (CTL). In addition, it was shown (a) that SMAF does not interfere with the in vitro cytotoxicity expressed by CTL and (b) that in addition to CTL memory cells, SMAF-producing memory cells were also induced after injection of syngeneic tumor cells. These data support the hypothesis that SMAF is involved in t...Continue Reading

References

Jan 1, 1989·Cancer Immunology, Immunotherapy : CII·R A De WegerW D Den Otter
Jan 1, 1986·Cancer Immunology, Immunotherapy : CII·H F DullensW D Den Otter
Jan 1, 1987·Cancer Immunology, Immunotherapy : CII·R A De WegerW D Den Otter
Jan 1, 1986·Methods in Enzymology·R A De Weger, W D Den Otter
May 15, 1985·International Journal of Cancer. Journal International Du Cancer·L RomaniM C Fioretti
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Jan 1, 1984·Cancer Immunology, Immunotherapy : CII·B A BlazarE Klein
Mar 1, 1984·Immunobiology·H Van LoverenW D Den Otter
Nov 1, 1985·Immunology Today·R A De WegerW D Den Otter

Citations

Jul 14, 1999·Archives of Pharmacal Research·S Pyo, D K Rhee
Dec 18, 2001·Journal of Ethnopharmacology·Nam Sung KangSuhkneung Pyo
Dec 29, 2005·Journal of Medicinal Food·Eun-Mi ChoiJae-Kwan Hwang
Jan 1, 1989·Cancer Immunology, Immunotherapy : CII·R A De WegerW D Den Otter
Jan 1, 1993·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·D Lovens-De GraefN Schaaf-Lafontaine
May 3, 2018·Basic & Clinical Pharmacology & Toxicology·Shilpa GuptaZabeer Ahmed
Mar 1, 1994·International Journal of Cancer. Journal International Du Cancer·J J BergersD J Crommelin

Related Concepts

Antigen-specific T cell factors
Metazoa
Immunologic Tumoricidal Activities
Immunologic Memory
Lymphokines
Macrophage Activation
Macrophage
Mice, Inbred Strains
Sarcoma, Jensen
T-Lymphocyte

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