PMID: 6540690Aug 1, 1984Paper

Production of systemic hyperthermia in the rat

European Journal of Cancer & Clinical Oncology
P F LordZ Weshler

Abstract

The design of clinical trials employing whole-body hyperthermia in cancer therapy has been hampered due to lack of a suitable animal model. We describe a technique for reproducibly and efficiently inducing whole-body hyperthermia in Sprague-Dawley rats, using halothane and oxygen anesthesia and immersion in a hot water bath. Core body temperatures of between 41.5 and 43 degrees C were induced and maintained for periods of up to 200 min and survival curves were determined. The time of exposure at a given temperature that resulted in death in 50% of the animals within 24 hr after heating (LD50/24 hr) was calculated by linear logistic regression analysis. LD50 24 hr values of 115, 61, 57, 25 and 16 min were obtained for temperatures of 41.75, 42.0, 42.25, 42.5 and 42.75 degrees C respectively. This heating technique is compared to several more toxic methods for inducing whole-body hyperthermia with respect to possible pharmacological and physiological differences.

References

May 1, 1977·Radiology·W C DeweyL E Gerweck
Mar 1, 1979·Annals of Internal Medicine·J M BullV T DeVita
Aug 1, 1979·The British Journal of Radiology·S P HumeS B Field
Feb 1, 1978·The British Journal of Radiology·M P LawS B Field
Jun 1, 1976·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A Yerushalmi
Dec 21, 1974·British Medical Journal·R T PettigrewA N Smith
Oct 1, 1971·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·E M Stricker, F R Hainsworth
Jun 1, 1983·International Journal of Radiation Oncology, Biology, Physics·D S Kapp, P F Lord
Jan 1, 1980·Annals of the New York Academy of Sciences·J A Dickson, S K Calderwood
Jan 1, 1980·Annals of the New York Academy of Sciences·K J Henle, L A Dethlefsen
Jan 1, 1982·International Journal of Radiation Oncology, Biology, Physics·K K AngE van der Schueren

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Citations

Mar 15, 1997·Annals of the New York Academy of Sciences·A A Romanovsky, C M Blatteis
Jul 17, 2012·European Journal of Pharmacology·Laure BarbierFrédéric Canini
Jan 1, 1994·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·P SminiaJ Haveman
Jan 21, 2006·Reviews on Environmental Health·Christopher J Gordon, Lisa R Leon
Dec 1, 1996·Journal of Applied Physiology·A A Romanovsky, C M Blatteis
Oct 22, 2005·Journal of Applied Physiology·Lisa R LeonDavid A DuBose
Mar 1, 1988·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·D A WilkinsonP N Shrivastava
Aug 1, 1994·The American Journal of Physiology·P L MoseleyM W Peterson

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