PMID: 11909629Mar 23, 2002Paper

Production of taxoids with biological activity by plants and callus culture from selected Taxus genotypes

Phytochemistry
Guy ParcMichèle Meyer

Abstract

Twenty seven different yew trees belonging to various genotypes and hybrids have been screened for their capacity to produce significant amounts of taxoids provided with biological activity in the tubulin test. From the three best genotypes selected, Taxus x media "Sargentii" proved to be able to produce viable calluses from excised roots placed in vitro. Taxoid composition at various times of the in vitro culture was determined and the carcinostatic efficiency of the extracts was established using the KB cell cytotoxicity test. In leaves and calluses, respectively, 0.069 and 0.032% paclitaxel (taxol) contents were found. These contents were significantly higher than those previously reported for other genotypes.

References

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Aug 1, 1996·Planta medica·S BanerjeeS K Chattopadhyay
Jul 1, 1993·Plant Cell Reports·D M GibsonA A Christen

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Citations

Mar 2, 2006·Chemical & Pharmaceutical Bulletin·Jungui DaiMasayoshi Ando
Oct 20, 2005·Journal of Bioscience and Bioengineering·Jian-Jiang Zhong
May 12, 2012·Molecular Ecology·C BurgarellaS C González-Martínez
Oct 21, 2015·Frontiers in Plant Science·Marcelo FridlenderHinanit Koltai
May 26, 2018·Molecular Biotechnology·Shu-Ling LinPing-Lan Ouyang

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