PMID: 16523155Mar 9, 2006Paper

Production of Th1/Th2 cytokines and nitric oxide in Behçet's uveitis and idiopathic uveitis

Journal français d'ophtalmologie
H GuenaneC Touil-Boukoffa

Abstract

The aim of this study was to investigate the role of Th1 (IFN-gamma and IL-12), Th2 (IL-10) cytokines and nitric oxide (NO) in the immunopathologic mechanisms of uveitis related to Behçet's disease and isolated idiopathic uveitis. This study was conducted on 24 patients with Behçet's syndrome who had active uveitis, ten of whom showed isolated uveitis classified as idiopathic uveitis, and 13 healthy controls. The levels of IFN-gamma, IL-12 and IL-10 in sera and supernatants of PBMC cultures stimulated by PHA were estimated using immunoenzymatic dosage (ELISA sandwich according to the methods recommended by Immunotech France). The production of NO was measured in vivo and in vitro for the same patients using the modified Griess method. The induction of IFN-gamma and IL-12 was higher in the two groups of patients than in the controls (P<0.001). Significant IL-10 levels were recorded in 56.5% of patients with Behçet's disease presenting uveitis versus 30% of patients with idiopathic uveitis. NO production was more pronounced in idiopathic uveitis than in Behçet's syndrome (P<0.02). The predominance of the Th1 profile was associated with high production of NO in idiopathic uveitis. A Th1/Th2 profile with a moderated increase in NO ...Continue Reading

Citations

Feb 19, 2015·International Journal of Inflammation·Houda BelguendouzChafia Touil-Boukoffa
Oct 21, 2018·Journal of Cellular Physiology·Arash SalmaninejadAmirhossein Sahebkar
Jul 31, 2020·International Ophthalmology·Abdullah Kursat CinguOrhan Ayyildiz
Jan 1, 2020·Journal of Inflammation·Elham ShahriyariMaryam Ghaffari Laleh
Apr 23, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Houda BelguendouzChafia Touil-Boukoffa
Dec 20, 2017·Archives of Dermatological Research·Ji Young YangEun-So Lee
May 5, 2017·Journal of Clinical Medicine·Alireza SadeghiMasoud Asadi-Khiavi
Mar 2, 2010·Molecular Biology Reports·Omer AteşAysegul Topal-Sarıkaya
Apr 12, 2012·Ocular Immunology and Inflammation·Fatmazohra Djaballah-IderChafia Touil-Boukoffa
Oct 27, 2006·Current Opinion in Ophthalmology
Jun 20, 2008·Journal français d'ophtalmologie·H BelguendouzC Touil-Boukoffa
Aug 20, 2008·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Abuzer GündüzAdnan Seyrek

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