Production of the amino acids l-glutamate, l-lysine, l-ornithine and l-arginine from arabinose by recombinant Corynebacterium glutamicum

Journal of Biotechnology
Jens SchneiderVolker F Wendisch

Abstract

Amino acid production processes with Corynebacterium glutamicum are based on media containing glucose from starch hydrolysis or fructose and sucrose as present in molasses. Simultaneous utilization of various carbon sources, including glucose, fructose and sucrose, in blends is a typical characteristic of this bacterium. The renewable non-food carbon source arabinose, which is present in hemicellulosic hydrolysates, cannot be utilized by most C. glutamicum strains. Heterologous expression of the araBAD operon from Escherichia coli in the wild-type and in an l-lysine producing strain of C. glutamicum was shown to enable production of l-glutamate and l-lysine, respectively, from arabinose as sole carbon source. l-Ornithine and l-arginine producing strains were constructed and shown to produce l-ornithine and l-arginine from arabinose when araBAD from E. coli was expressed. Moreover, the recombinant strains produced l-glutamate, l-lysine, l-ornithine and l-arginine respectively, from arabinose also when glucose-arabinose blends were used as carbon sources.

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Citations

Jul 28, 2010·Applied Microbiology and Biotechnology·Jens Schneider, Volker F Wendisch
Apr 27, 2011·Applied Microbiology and Biotechnology·Jan Nešvera, Miroslav Pátek
Jul 29, 2011·Applied Microbiology and Biotechnology·Vipin GopinathK Madhavan Nampoothiri
Nov 19, 2011·Applied Microbiology and Biotechnology·Vipin GopinathK Madhavan Nampoothiri
Jul 10, 2013·Journal of Industrial Microbiology & Biotechnology·Ling-Yan JiangJian-Zhong Liu
Apr 9, 2013·Applied Biochemistry and Biotechnology·Meijuan XuZhenghong Xu
Apr 9, 2013·Bioresource Technology·Tobias M MeiswinkelVolker F Wendisch
Jun 29, 2013·Microbial Cell Factories·Jaide Vold Korgaard Jensen, Volker Fritz Wendisch
Mar 29, 2014·Applied Microbiology and Biotechnology·Christian MatanoGerd M Seibold
Aug 6, 2014·Nature Communications·Seok Hyun ParkSang Yup Lee
Jun 4, 2013·BMC Biotechnology·Ling-Yan JiangJian-Zhong Liu
Feb 2, 2016·ACS Synthetic Biology·Sara CletoTimothy K Lu
Dec 4, 2014·Microbial Cell Factories·Jae Ho Shin, Sang Yup Lee
Dec 29, 2015·Biotechnology Journal·Fangyu ChengGregory Stephanopoulos
Dec 21, 2014·Folia Microbiologica·Yuan-Yuan ZhangJian-Zhong Liu
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Jan 1, 2012·Computational and Structural Biotechnology Journal·Ahmed ZahoorVolker F Wendisch
Dec 5, 2014·Applied Microbiology and Biotechnology·Xiping LiuKun Zhu
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Jun 29, 2016·Applied Microbiology and Biotechnology·Dorit LubitzVolker F Wendisch
Aug 6, 2016·BMC Microbiology·Christian MatanoVolker F Wendisch
Oct 9, 2016·BMC Microbiology·Dorit Lubitz, Volker F Wendisch
Dec 23, 2016·Journal of Industrial Microbiology & Biotechnology·Jingjing ZhangZhiming Rao
Feb 9, 2017·Biotechnology Journal·Fernando Pérez-GarcíaVolker F Wendisch
May 6, 2015·Chemical Society Reviews·Xinxiao SunQipeng Yuan
Mar 21, 2018·Applied Microbiology and Biotechnology·Kei-Anne BaritugoSi Jae Park
Mar 10, 2018·Applied Microbiology and Biotechnology·Volker F WendischFernando Pérez-García
Dec 9, 2017·Frontiers in Microbiology·Maria K McClintockKechun Zhang
Apr 15, 2018·Journal of Industrial Microbiology & Biotechnology·Jie ChengQinhong Wang

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