PMID: 9546156Apr 18, 1998Paper

Production of the carotenoids lycopene, beta-carotene, and astaxanthin in the food yeast Candida utilis

Applied and Environmental Microbiology
Y MiuraNorihiko Misawa

Abstract

The food-grade yeast Candida utilis has been engineered to confer a novel biosynthetic pathway for the production of carotenoids such as lycopene, beta-carotene, and astaxanthin. The exogenous carotenoid biosynthesis genes were derived from the epiphytic bacterium Erwinia uredovora and the marine bacterium Agrobacterium aurantiacum. The carotenoid biosynthesis genes were individually modified based on the codon usage of the C. utilis glyceraldehyde 3-phosphate dehydrogenase gene and expressed in C. utilis under the control of the constitutive promotes and terminators derived from C. utilis. The resultant yeast strains accumulated lycopene, beta-carotene, and astaxanthin in the cells at 1.1, 0.4, and 0.4 mg per g (dry weight) of cells, respectively. This was considered to be a result of the carbon flow into ergosterol biosynthesis being partially redirected to the nonendogenous pathway for carotenoid production.

References

Jan 1, 1992·Critical Reviews in Biotechnology·H BozeP Galzy
Dec 6, 1995·Journal of the National Cancer Institute·E GiovannucciW C Willett
Jun 1, 1994·Bioscience, Biotechnology, and Biochemistry·S YamanoN Misawa

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Citations

Jan 6, 2007·Journal of Industrial Microbiology & Biotechnology·Rick W YeEdward S Miller
Jul 30, 2014·Natural Product Reports·Myoung Chong SongYeo Joon Yoon
Jan 23, 2020·Journal of Applied Genetics·Ján KrahulecJán Turňa
Jan 17, 2007·Applied Microbiology and Biotechnology·R RajaR Rengasamy
Dec 17, 2003·The Plant Journal : for Cell and Molecular Biology·Kjell StålbergAnna-Stina Höglund
Jun 24, 2010·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Martín MolinéMaría van Broock
Jun 18, 2011·Microbiology·Christoph BuerthDenis Tielker
Apr 2, 2014·Applied Microbiology and Biotechnology·Sabine A E HeiderTrygve Brautaset
Nov 28, 2013·Journal of Analytical Methods in Chemistry·Rama Raju BaadheYalavarthy Prameela Devi
Jan 15, 2019·Critical Reviews in Food Science and Nutrition·K Srinivasan, Elna M Buys
Jul 27, 2004·The Plant Journal : for Cell and Molecular Biology·Louise RalleyPaul D Fraser
Nov 5, 2008·Journal of Industrial Microbiology & Biotechnology·Ginka I Frengova, Dora M Beshkova
Nov 4, 2010·Applied Microbiology and Biotechnology·Isabell SchmidtJens Schrader
May 31, 2013·FEMS Microbiology Letters·Qian LiYansheng Zhang
Jan 1, 2014·Applied and Environmental Microbiology·Falk MatthäusGerold Barth
Apr 19, 2013·Journal of Molecular Microbiology and Biotechnology·Frank SonntagJens Schrader
Feb 11, 2014·Photosynthesis Research·Fiona K DaviesMatthew C Posewitz
Dec 31, 2015·World Journal of Microbiology & Biotechnology·Tian MaTiangang Liu
Jul 1, 2016·Applied Microbiology and Biotechnology·Christoph BuerthJoachim F Ernst
Aug 11, 2020·International Journal of Food Science·Tatas Hardo Panintingjati Brotosudarmo Heriyanto
May 10, 2000·Nature Biotechnology·W R Farmer, J C Liao
Dec 6, 2011·FEMS Yeast Research·Michael S SiddiquiChristina D Smolke
Dec 14, 2011·Applied Microbiology and Biotechnology·J M Araya-GarayT G Villa
Aug 21, 2007·Biotechnology and Bioengineering·Mohammad A AsadollahiJens Nielsen
Jun 21, 2006·Biotechnology Letters·Sung-Woo KimJoon-Ki Jung
Apr 25, 2013·Applied Microbiology and Biotechnology·Maya KunigoJoachim F Ernst
Oct 15, 2013·Biotechnology and Bioengineering·Jifeng Yuan, Chi Bun Ching
Aug 7, 2012·Applied and Environmental Microbiology·Guo-Shu WangRobin Ghosh
Jul 14, 2020·Current Genomics·Zeba UsmaniRajeev Bhat
Sep 15, 2005·Biotechnology and Bioengineering·JingHong M DejongRodney B Croteau
Aug 14, 2010·Photosynthesis Research·Yves Lemoine, Benoît Schoefs
May 12, 2015·Chemical Society Reviews·Yunzi LuoYing-Jin Yuan
Dec 5, 2003·Nature Reviews. Drug Discovery·Chaitan Khosla, Jay D Keasling
Jan 14, 2021·Journal of Fungi·Maria Sousa-SilvaIsabel Soares-Silva

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