Production of the chemokine eotaxin-1 in osteoarthritis and its role in cartilage degradation

Journal of Cellular Biochemistry
Yi-Hsin HsuChien-Ho Chen

Abstract

The expression of the chemokine, eotaxin-1, and its receptors in normal and osteoarthritic human chondrocytes was examined, and its role in cartilage degradation was elucidated in this study. Results indicated that plasma concentrations of eotaxin-1 as well as the chemokines, RANTES, and MCP-1alpha, were higher in patients with osteoarthritis (OA) than those in normal humans. Stimulation of chondrocytes with IL-1beta or TNF-alpha significantly induced eotaxin-1 expression. The production of eotaxin-1 induced expression of its own receptor of CCR3 and CCR5 on the cell surface of chondrosarcomas, suggesting that an autocrine/paracrine pathway is involved in eotaxin-1's action. In addition, eotaxin-1 markedly increased the expressions of MMP-3 and MMP-13 mRNA, but had no effect on TIMP-1 expression in chondrocytes. However, pretreatment of anti-eotaxin-1 antibody significantly decreased the MMP-3 expression induced by IL-1beta. These results first demonstrate that human chondrocytes express the chemokine, eotaxin-1, and that its expression is induced by treatment with IL-1beta and TNF-alpha. The cytokine-triggered induction of eotaxin-1 further results in enhanced expressions of its own receptor of CCR3, CCR5, and MMPs, suggesting...Continue Reading

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Citations

Sep 28, 2013·Current Rheumatology Reports·Xavier HouardFrancis Berenbaum
Nov 26, 2011·Journal of Biomedical Science·Pin-Zhir ChaoChien-Ho Chen
Aug 12, 2014·European Journal of Immunology·David LuckeyVeena Taneja
Nov 7, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Karen L PoseyJacqueline T Hecht
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Nov 11, 2020·Journal of Orthopaedic Surgery and Research·Feifei NiJianjun Li
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May 18, 2021·Frontiers in Veterinary Science·Lynn PezzaniteLaurie Goodrich
Jul 22, 2021·Current Issues in Molecular Biology·Isabel Olmos CalvoZsombor Lacza

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