PMID: 7513016May 1, 1994Paper

Production of the RANTES chemokine in delayed-type hypersensitivity reactions: involvement of macrophages and endothelial cells

The Journal of Experimental Medicine
O DevergneT Kim

Abstract

To understand the selective accumulation of memory T helper lymphocytes and of macrophages in delayed-type hypersensitivity (DTH) granulomas, we studied the in situ production of RANTES, a chemokine initially characterized on the basis of its in vitro chemotactic properties for each of these cell populations. RANTES gene expression was studied by in situ hybridization in 15 human lymph nodes presenting typical DTH lesions related to either sarcoidosis or tuberculosis. A positive signal was detected in all cases. Labeling was specific for the DTH lesions, as very few if any positive cells were detected in the normal residual lymphoid tissue surrounding them or in reactive lymph nodes involved in a B lymphocyte response. RANTES gene expression was associated with the production of the protein, which was detected by immunochemistry in DTH lymph nodes. The morphological characteristics and distribution of positive cells in in situ hybridization and immunochemical experiments indicated that macrophages and endothelial cells, two cell populations not previously reported to produce RANTES, contributed to its production in DTH reactions. The ability of macrophages and endothelial cells to produce RANTES was confirmed by in vitro studie...Continue Reading

References

Aug 1, 1992·The Journal of Experimental Medicine·Y KameyoshiJ M Schröder
Jun 1, 1992·Immunology Today·M Howard, A O'Garra
May 1, 1991·Cytokine·T J Schall
Sep 1, 1991·The Journal of Experimental Medicine·J B HaanenH Spits
Jan 1, 1991·Annual Review of Immunology·J J OppenheimK Matsushima
Jul 1, 1990·The Journal of Clinical Investigation·D EmilieP Galanaud
Nov 1, 1989·Immunology Today·A Mantovani, E Dejana
Jul 1, 1983·Journal of Clinical Pathology·G T Williams, W J Williams

❮ Previous
Next ❯

Citations

Mar 10, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·L M Gale, S R McColl
Mar 4, 1998·European Journal of Immunology·S J RothT A Springer
Sep 1, 1994·The Clinical Investigator·A J HabenichtG Schettler
Feb 1, 1996·Medical Microbiology and Immunology·H MollC Blank
Dec 1, 1994·Current Opinion in Immunology·T J Schall, K B Bacon
Mar 24, 2004·Cytokine·Masashi OhtaniNaoko Watanabe
Jan 5, 2002·European Journal of Pharmacology·N LazzeriJ A Mitchell
Sep 2, 1998·Transplantation Proceedings·M J WilhelmN L Tilney
Apr 1, 1997·Molecular Aspects of Medicine·C AgostiniD G James
Jan 23, 1998·Peptides·A Maffei, P E Harris
Apr 3, 2003·Journal of Dermatological Science·Hiroyuki OkamotoTakeshi Horio
Dec 16, 2000·Allergy·G SemenzatoC Agostini
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·K C NadeauN L Tilney
Apr 23, 2011·DNA and Cell Biology·Walid Ben-SelmaJalel Boukadida
Dec 8, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Madhan Kumar MurthyAlamelu Raja
Dec 3, 2009·International Immunology·Praveen DeepakArbind Acharya
Jan 27, 2000·Current Opinion in Rheumatology·C AgostiniG Semenzato
Nov 5, 1997·Journal of Pediatric Gastroenterology and Nutrition·D BerrebiM Peuchmaur
Jul 4, 2001·Transplantation·J J YunA Ardehali
Aug 13, 2002·Current Opinion in Pulmonary Medicine·Carlo AgostiniGianpietro Semenzato
Jun 5, 2007·Current Opinion in Gastroenterology·Silvio Danese
Nov 14, 1997·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J M BlackwellM A Shaw
Feb 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M Humbert
Aug 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P KunaA P Kaplan
Jun 25, 1998·Transplant International : Official Journal of the European Society for Organ Transplantation·C C Baan, W Weimar
Oct 12, 1999·American Journal of Reproductive Immunology : AJRI·G B AltmanC Baker
Aug 15, 1998·Annals of the New York Academy of Sciences·A MantovaniM Introna

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.