Production of the Shwartzman reaction with microbial L forms.

Journal of Bacteriology
G M KalmansonL B Guze

Abstract

Study of potential pathogenicity of microbial L forms was done by the localized Shwartzman reaction. Stable L forms of Proteus mirabilis served as skin preparation in rabbits for induction of Shwartzman reaction by subsequent intravenous injection of either P. mirabilis L forms or Escherichia coli endotoxin. The intensity of the reaction was positively correlated to numbers of L forms in the skin. L forms also served as the intravenous challenge. In vivo multiplication of L forms was not a prerequisite for the reaction, as it could be produced with nonviable, osmotically lysed L forms. The reaction produced with L forms in the skin was more intense than that produced with the parent bacterial form. These latter observations, coupled with the demonstration that L forms disappeared from the skin (lysed?) after 4 hr, in contrast to bacteria which were recoverable for 72 hr (duration of study), suggest release of endotoxin by L forms as a pathogenic mechanism.

References

Mar 1, 1966·Journal of Bacteriology·R Rosner
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Jul 1, 1963·Proceedings of the Society for Experimental Biology and Medicine·B A FREEMANW BURROWS
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Mar 27, 1965·Nature·C W GODZESKIH R BLACK
Jan 1, 1960·The Journal of Experimental Medicine·C L LARSONJ E LIEBERMAN

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Citations

Nov 20, 1969·The New England Journal of Medicine·D S Feingold

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