PMID: 8610221Jan 1, 1995Paper

Production of TNF by monocytes of patients with early rheumatoid arthritis is increased

Scandinavian Journal of Rheumatology
M Leirisalo-RepoH Repo

Abstract

We studied the production of tumour necrosis factor alpha (TNF) by monocytes of patients with early rheumatoid arthritis (RA) before starting disease modifying anti-rheumatic drug treatment and a median 6 months (range 5-11 months) later, and correlated the pre-treatment results with 3-year prognosis. Monocytes of patients (n = 14) and controls (n = 14), isolated by the density gradient centrifugations, were cultured for 24 h with Escherichia coli lipopolysaccharide (LPS) 0-10 micrograms/ml. Before treatment, levels of TNF were higher in LPS-stimulated RA monocyte cultures than in the control cultures; differences were statistically significant in LPS 10 and 0.01 micrograms/ml. At 6 months, respective differences were not significant. Levels of TNF before treatment did not correlate to clinical or laboratory parameters of inflammation, or development of erosions. The results indicate that monocytes of patients with early RA are primed, and that the state of priming decreases during treatment.

References

Jan 1, 1992·The Clinical Investigator·B HeiligW Hunstein
Feb 1, 1991·The Journal of Clinical Investigation·M SeitzM Baggiolini
Jul 1, 1991·Arthritis and Rheumatism·L PaimelaM Leirisalo-Repo
Aug 1, 1993·Inflammation·M Leirisalo-RepoH Repo
Mar 1, 1993·The Journal of Clinical Investigation·G HahnG R Burmester

❮ Previous
Next ❯

Citations

Aug 25, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·L B Hughes, L W Moreland
Nov 10, 2010·Journal of Clinical Pharmacology·Cathye ShuDonald Raible
Aug 22, 2018·Journal of the Belgian Society of Radiology·Paolo Simoni
Jul 19, 2014·World Journal of Orthopedics·Grant W MalloryMichelle J Clarke
May 25, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·John M DavisSherine E Gabriel
Feb 6, 2020·Biological & Pharmaceutical Bulletin·Naofumi UesatoMutsuyoshi Matsushita

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved