Production of tumor necrosis factor alpha and hemodialysis

Nephron
C MacdonaldR M McKenna

Abstract

The production of TNF alpha by peripheral blood mononuclear cells (PBMC) was determined in 18 hemodialysis (HD) patients. Blood was taken from each patient before and after an HD treatment. Both pre- and post-HD PBMC produced significantly more TNF alpha than controls (TNF alpha units/ml; mean +/- SEM; controls 3.1 +/- 0.7; pre-HD 9.7 +/- 3.9; post-HD 19.8 +/- 7.7, p < 0.05). In addition, post-HD PBMC produced significantly more TNF alpha than pre-HD PBMC suggesting that the HD procedure itself may activate cytokine production. This was true when PBMC were cultured in serum free medium as well as on culture with non-HD sera (human AB) and autologous sera. A positive correlation was also found between the production of TNF alpha and age in HD patients (r = 0.58; p < 0.01). Finally, normal PBMC cultured in post-HD sera produced significantly less TNF alpha than when cultured in the same sera pre-HD (p < 0.02). These findings suggest that PBMC of HD patients are chronically stimulated to produce TNF alpha which may contribute to some of the short-term and long-term complications of HD.

Citations

Jan 1, 1997·International Urology and Nephrology·M Kozioł-MontewkaE Przylepa
Nov 14, 1997·Immunology Today·A EiglerS Endres
Oct 10, 1998·Kidney International·M GoicoecheaC Caramelo
May 15, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pedro Iglesias, Juan J Díez
Jan 3, 2007·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Abelardo AguileraRafael Selgas
Jan 14, 2004·Seminars in Dialysis·Abelardo AguileraRafael Selgas
Feb 5, 2002·Expert Opinion on Pharmacotherapy·A AguileraV Alvarez
Jan 23, 1999·The Journal of Nutrition·J D Kopple

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