Production of tumor necrosis factor, interleukin 1, and interferon-gamma by peripheral blood mononuclear cells from patients with primary biliary cirrhosis

Clinical Immunology and Immunopathology
S KakumuM Arao

Abstract

Since patients with primary biliary cirrhosis (PBC) have evidence of abnormal function of the immune system, we evaluated production of various cytokines by peripheral blood mononuclear cells (PBMCs) and monocytes from patients with this disease, using an enzyme-linked immunosorbent assay. The mean amounts of production of tumor necrosis factor alpha(TNF alpha), interleukin 1 beta (IL1 beta), and interferon-gamma (IFN-gamma) by PBMCs from patients with PBC tended to be increased in cultures in the presence of stimulating agents in comparison with controls, but there was no significant difference because of a wide scatter of results. Monocytes from PBC patients also tended to produce higher amounts of TNF alpha and IL1 beta than control monocytes did, although the percentage of monocytes in PBMCs was similar in PBC and controls. A significant correlation was found between TNF alpha production and IL1 beta production in PBC patients. The number of TNF alpha or IFN-gamma positive infiltrating mononuclear cells detected by immunohistochemical staining in liver biopsy sections correlated with the production of these cytokines by PBMCs in vitro. However, cytokine production did not correlate with serum biochemical or hepatic histolog...Continue Reading

References

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Citations

Jun 10, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Katherine L LeicesterBruce R Bacon
Feb 14, 1992·Biochemical and Biophysical Research Communications·M OnoN Taniguchi
Sep 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y CalmusR Poupon
Aug 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L C MillerM M Kaplan
Mar 19, 2003·Liver International : Official Journal of the International Association for the Study of the Liver·Shinichiro HanadaMichio Sata

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