PMID: 2437390Apr 1, 1987

Production of tumor-specific suppressor T cell hybridomas

The Journal of Surgical Research
H D Bear

Abstract

Spleen cells from late tumor-bearing host mice (TBH) with progressive P815 tumors have been shown to suppress the generation of cytotoxic T lymphocytes (CTL) from spleens of syngeneic immune or early TBH mice in vitro. This suppression is antigen-specific and is mediated by T lymphocytes. By positive selection, a highly enriched population of T cells was obtained from late TBH spleens and fused with the BW5147 HAT-sensitive thymoma. Cloned hybrid cell lines were obtained which released soluble antigen-specific factors capable of suppressing anti-P815 CTL generation. Similar T cell hybrids with suppressive activity were also derived from the fusion of spleen cells of TBHs bearing a HAT-sensitive subline of the P815 tumor.

References

Jan 1, 1986·Annual Review of Immunology·G L AshersonM Zembala
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·K NelsonK E Hellström
Jan 1, 1982·Clinical Immunology and Immunopathology·R Businaro, R Revoltella

Citations

Jan 1, 1990·Cancer Immunology, Immunotherapy : CII·J G McKinnonH D Bear
Jan 1, 1990·Cancer Immunology, Immunotherapy : CII·S K HooverH D Bear

Related Concepts

Monoclonal Antibodies
Antigenic Specificity
Tumor Antigens
Hybridomas
Lymphoma
Mice, Inbred DBA
Mast-Cell Sarcoma
TC2 Cells
Tr1 Cells

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