Production of Useful Terpenoids by Higher-Fungus Cell Factory and Synthetic Biology Approaches

Trends in Biotechnology
Han Xiao, Jian-Jiang Zhong

Abstract

Higher fungi with greater than 70000 species are regarded as a rich source of various natural compounds including terpenoids, the production of which represents a wide range of interest in pharmaceutical and healthcare industries. This review summarizes the current knowledge of terpenoids synthesized by higher fungi, and highlights the current state-of-the-art regarding genetic manipulation of higher fungi. As the focus, this article will discuss the most recent approaches enabling native hosts and heterologous microbes to efficiently produce various terpenoids, especially with regard to the construction of 'smart' higher-fungus cell factories. The merits and demerits of heterologous versus native hosts as cell factories will also be debated.

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Citations

Apr 2, 2017·Trends in Biotechnology·Jie WangJian-Jiang Zhong
Oct 21, 2018·The Plant Journal : for Cell and Molecular Biology·Yi Shang, Sanwen Huang
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Dec 19, 2021·Applied Microbiology and Biotechnology·Wen-Fang WangJian-Jiang Zhong

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