Production Options for Psilocybin: Making of the Magic

Chemistry : a European Journal
Janis FrickeDirk Hoffmeister

Abstract

The fungal genus Psilocybe and other genera comprise numerous mushroom species that biosynthesize psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine). It represents the prodrug to its dephosphorylated psychotropic analogue, psilocin. The colloquial term "magic mushrooms" for these fungi alludes to their hallucinogenic effects and to their use as recreational drugs. However, clinical trials have recognized psilocybin as a valuable candidate to be developed into a medication against depression and anxiety. We here highlight its recently elucidated biosynthesis, the concurrently developed concept of enzymatic in vitro and heterologous in vivo production, along with previous synthetic routes. The prospect of psilocybin as a promising therapeutic may entail an increased demand, which can be met by biotechnological production. Therefore, we also briefly touch on psilocybin's therapeutic relevance and pharmacology.

References

Oct 1, 1968·Journal of Pharmaceutical Sciences·A Y Leung, A G Paul
Feb 1, 1968·Tetrahedron Letters·S Agurell, J L Nilsson
Jan 1, 1968·Acta Chemica Scandinavica·S Agurell, J L Nilsson
Jan 1, 1994·Journal of Basic Microbiology·J Gartz
Nov 15, 1958·Experientia·A HOFMANNF TROXLER
Oct 28, 2003·Addiction Biology·Torsten PassieHinderk M Emrich
Dec 1, 2006·Chemical Communications : Chem Comm·Rebecca J M Goss, Philip L A Newill
Jan 25, 2007·Planta medica·Mathias Misiek, Dirk Hoffmeister
May 20, 2008·Trends in Biochemical Sciences·Michael F DunnIlme Schlichting
Jul 3, 2008·Journal of Psychopharmacology·Mw JohnsonRr Griffiths
Nov 3, 2010·Lancet·David J NuttUNKNOWN Independent Scientific Committee on Drugs
Jun 13, 2013·Nature Reviews. Neuroscience·David J NuttDavid E Nichols
Jan 22, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Filip TylšJiří Horáček
Feb 9, 2016·Journal of Natural Products·David J Newman, Gordon M Cragg
Jun 30, 2016·Journal of the American Chemical Society·Michael HergerFrances H Arnold
Dec 23, 2016·Chembiochem : a European Journal of Chemical Biology·Daniel FrancisJason Micklefield
Jun 7, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Matthew W Johnson, Roland R Griffiths
Aug 2, 2017·Angewandte Chemie·Janis FrickeDirk Hoffmeister
Sep 21, 2017·Journal of Natural Products·Claudius LenzDirk Hoffmeister
Dec 12, 2017·Expert Review of Clinical Pharmacology·Alexander M Sherwood, Thomas E Prisinzano

❮ Previous
Next ❯

Citations

Jun 1, 2019·Chembiochem : a European Journal of Chemical Biology·Janis FrickeDirk Hoffmeister
Nov 26, 2020·ChemPlusChem·Claudius LenzDirk Hoffmeister
Jan 2, 2021·Forensic Science International : Synergy·Nicole S Jones, Jeffrey H Comparin
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Henry LoweLorenzo Gordon
Jun 11, 2021·Frontiers in Bioengineering and Biotechnology·Suhad A A Al-SalihiGary D Foster
Jul 31, 2021·F1000Research·Kevin McKernanStephen McLaughlin
Jun 2, 2021·Chemistry : a European Journal·Claudius LenzDirk Hoffmeister

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Related Papers

Schweizer Archiv für Neurologie, Neurochirurgie und Psychiatrie = Archives suisses de neurologie, neurochirurgie et de psychiatrie
F GNIRSS
Medicina
Dagmara ReingardieneRobertas Lazauskas
© 2022 Meta ULC. All rights reserved