PMID: 7334933Dec 1, 1981Paper

Production rates of androgens and oestrogens in post-menopausal women

Maturitas
C LongcopeG Griffing

Abstract

The production rate (PR) values of delta 4-androstenedione (A), testosterone (T), oestrone (E1) and oestradiol (E2) have been determined in a large group of post-menopausal women following constant infusions of radiolabelled hormones and radioimmunoassay of endogenous steroid concentration. The mean +/- SE age was 64 +/- 2 yr, ranging from 46 to 91 yr and the mean +/- SE weight was 144 +/- 4 lb. When the PR values were related to age by linear regression analysis no significant correlation could be found for PRA, PRT or PRE1 and the age of the subjects. There was, however, a significant correlation between PRE2 and age. There was a significant correlation between the PR values for each of the four steroids and the weights and body surface areas of the subjects. In addition, PRA correlated directly with both PRT and PRE1 in these subjects in which both PR values were measured. The PR values for each steroid were significantly smaller in the post-menopausal women compared to the mean PR values of a large group of pre-menopausal women. We conclude that age, per se, does not appear to influence the PR values for A, T and E1 but does for E2. The subjects weight, however, has a major influence for the PR values of all four steroids.

References

Jan 1, 1976·The Journal of Clinical Endocrinology and Metabolism·T MurakamiN Ohsawa
Aug 1, 1978·The Journal of Clinical Endocrinology and Metabolism·J H Pratt, C Longcope
Feb 1, 1979·Clinical Endocrinology·R G CrillyB E Nordin
Jul 1, 1979·Journal of Steroid Biochemistry·A Vermeulen, L Verdonck
Jul 1, 1978·Clinical Endocrinology·A Vermeulen, L Verdonck
Jan 1, 1978·The Journal of Clinical Endocrinology and Metabolism·C LongcopeS E Fineberg
Nov 1, 1976·The Journal of Clinical Endocrinology and Metabolism·C LongcopeS E Fineberg
Jul 1, 1973·The Journal of Clinical Endocrinology and Metabolism·J PoortmanF Schwarz
Feb 1, 1973·The Journal of Clinical Endocrinology and Metabolism·J M GrodinP C MacDonald
Mar 1, 1974·The Journal of Clinical Endocrinology and Metabolism·D L HemsellP C MacDonald
Jan 1, 1966·Acta Obstetricia Et Gynecologica Scandinavica·M Furuhjelm
Nov 1, 1980·American Journal of Obstetrics and Gynecology·C LongcopeC Franz
Jan 9, 2001·Trends in Cell Biology·K Sadler
Apr 1, 1954·Journal of Gerontology·G PINCUSJ CARLO
Oct 1, 1961·The Journal of Clinical Endocrinology and Metabolism·C D WESTE ENGLERT
Jun 1, 1962·The Journal of Clinical Endocrinology and Metabolism·P MLYNARYKC J PATTEE

❮ Previous
Next ❯

Citations

Jun 1, 1985·Metabolism: Clinical and Experimental·C C JohnstonC Longcope
Mar 1, 1997·Primary Care·H L Thacker
Jul 1, 1997·Baillière's Clinical Endocrinology and Metabolism·G M Prelevic, H S Jacobs
Nov 29, 2011·Rheumatology·Manjari LahiriIan N Bruce
Nov 26, 1999·Clinical Obstetrics and Gynecology·K M Hoeger, D S Guzick
Dec 29, 1995·Annals of the New York Academy of Sciences·A Vermeulen
Jul 21, 2011·The Journal of Sexual Medicine·Glenn D BraunsteinMichael P Caulfield
Feb 1, 1991·Annals of Epidemiology·M SowersS Updike
Feb 24, 2009·Primary Care·David G Weismiller
Mar 1, 1986·Metabolism: Clinical and Experimental·C LongcopeC C Johnston
Dec 1, 1988·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J R BuchananL M Demers
Mar 28, 2018·The Journal of Clinical Endocrinology and Metabolism·Sasha SavkovicDavid J Handelsman
Nov 1, 1994·Postgraduate Medicine·George T Griffing, Susan H Allen
Jun 5, 2020·American Journal of Obstetrics and Gynecology·Nathan G KaseDerek LeRoith

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.