Feb 26, 2016

Productive infection of field strains of avian coronavirus infectious bronchitis virus in chicken peripheral blood-derived monocyte

BioRxiv : the Preprint Server for Biology
Yueting Zhang, Gary Whittaker

Abstract

The avian coronavirus infectious bronchitis virus (IBV) typically infects the respiratory tract of chickens, but can also spread to other organs. However, the mechanisms of virus dissemination are presently unclear. We show that peripheral blood-derived monocytes/macrophages from chickens (chPBMC) are productively infected by clinical strains of IBV, accompanied by induction of apoptosis. Our data suggest that chPBMCs play a role in the dissemination of IBV, and may be important for viral pathogenesis.

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Mentioned in this Paper

Virus
Respiratory Tract Structure
Peripheral Blood
Infectious bronchitis virus
Viral Pathogenesis
Respiratory System
Organ
Apoptosis
Monocytes as Percentage of Blood Leukocytes (Lab Test)
Macrophage

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis