PMID: 8608942Apr 15, 1996Paper

Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo

Genes & Development
E S HoffmanA C Hayday

Abstract

Productive gene rearrangement at the T-cell receptor (TCR) beta-chain locus facilitates formation of the "pre-TCR," a molecular complex that is important for the subsequent development of alpha beta T cells. The transition of thymocytes from a population of cells undergoing TCRbeta chain genes to a population enriched in cells with productively rearranged TCRbeta chain genes is known as "beta selection." This is the first point in alpha beta T-cell development at which the products of an activated TCR locus define cell phenotype. Toward an understanding of these events, this study has focused on a set of thymocytes defined by cell surface phenotype as HSA+ CD44low CD25+, in which the bulk of TCRbeta gene rearrangement occurs. The analysis of this set, presented here, allows its novel subdivision into two subsets that are respectively strong candidates for cells immediately prior to and immediately following TCRbeta selection. Cells that have passed beta selection differ from the preceding cells by several criteria, including hyperphosphorylation of Rb, increased expression of cyclins A and B, down-regulation of p27, increased CDK2 activity, an induction of cdc2 activity, and progression through DNA synthesis. Consistent with th...Continue Reading

References

Jan 1, 1976·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H A CrissmanJ A Steinkamp
Apr 1, 1992·Molecular Biology of the Cell·R L MarraccinoJ M Roberts
Jan 1, 1992·Advances in Immunology·E V Rothenberg
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J A DeCaprioD M Livingston
Mar 6, 1992·Cell·P MombaertsV E Papaioannou
May 29, 1992·Cell·D KitamuraK Rajewsky
Nov 30, 1990·Cell·M J SolomonM W Kirschner
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M PearseR Scollay
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·K G WimanW S Hayward
Jun 1, 1995·Current Biology : CB·E C DudleyA C Hayday
Jun 1, 1995·Immunology Today·W C Lin, S Desiderio
May 15, 1995·Genes & Development·C J Sherr, J M Roberts
Nov 18, 1994·Science·C Saint-RufH von Boehmer
Jan 1, 1994·Annual Review of Immunology·E Robey, B J Fowlkes
Apr 1, 1994·The Journal of Experimental Medicine·A WilsonH R MacDonald
Oct 15, 1993·Science·E PadovanA Lanzavecchia
Mar 26, 1993·Science·M Ohtsubo, J M Roberts

❮ Previous
Next ❯

Citations

Jan 16, 2009·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Erin PaulJan E Klysik
Jul 11, 1998·Biochimica Et Biophysica Acta·M A FarrarK Sauer
Mar 1, 2002·Current Opinion in Immunology·Bernard Khor, Barry P Sleckman
Apr 1, 1997·Current Opinion in Immunology·H J Fehling, H von Boehmer
May 29, 1998·Current Opinion in Immunology·J P Di Santo, H R Rodewald
May 14, 1999·Current Opinion in Immunology·H von BoehmerO Azogui
Sep 11, 2002·Seminars in Immunology·Yolanda R CarrascoMaría L Toribio
Mar 29, 2001·Nature Immunology·N C DouglasA C Hayday
Jul 19, 2005·Nature Immunology·Fotini GounariKhashayarsha Khazaie
Jan 24, 2007·Nature Immunology·Adrian C Hayday, Daniel J Pennington
Dec 22, 2007·Nature Reviews. Immunology·Ellen V RothenbergMary A Yui
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·C A Mallick-WoodA C Hayday
Dec 22, 1998·The Journal of Experimental Medicine·H S AzzamP E Love
Aug 3, 1999·The Journal of Experimental Medicine·I AifantisH von Boehmer
Dec 10, 1999·The Journal of Experimental Medicine·A M MichieJ C Zúñiga-Pflücker
Oct 19, 1999·The Journal of Experimental Medicine·S WinandyK Georgopoulos
Jul 6, 2000·The Journal of Experimental Medicine·P S CostelloD A Cantrell
Sep 6, 2001·The Journal of Experimental Medicine·D GibbonsA C Hayday
Mar 5, 2003·The Journal of Experimental Medicine·Abdelbasset HamrouniJanet L Maryanski
Oct 22, 2003·The Journal of Experimental Medicine·Eckart SchottHidde L Ploegh
Jul 25, 2007·The Journal of Experimental Medicine·Takeshi EgawaDan R Littman
Jul 4, 2007·The Journal of Experimental Medicine·Emil H Palacios, Arthur Weiss
Jan 28, 2009·The Journal of Experimental Medicine·Timothy J NiceDavid H Raulet
Aug 8, 2012·The Journal of Experimental Medicine·Hridesh BanerjeeSatyajit Rath
Jan 10, 2012·Carcinogenesis·Kwame Osei-SarfoAngel Pellicer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Cycle Pathways

Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.