Products of cyclooxygenase-2 depress duodenal function in rats subjected to abdominal surgery

Acta Physiologica
L Pihl, O Nylander

Abstract

Abdominal surgery evokes powerful biological responses that affect gastrointestinal functions. Here we investigate the role of the cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) isoforms in post-operative duodenal ileus. Proximal duodenum of anesthetized rats was perfused in situ with isotonic or hypotonic (50 mM) NaCl. Mucosal bicarbonate secretion, motility, mucosal permeability and effluent osmolality were determined in the absence and presence of different COX inhibitors. The majority of control animals had no or few duodenal contractions and bicarbonate secretion averaged 10.9 +/- 1.4 micromol cm(-1) h(-1). These 'paralytic' controls responded to hypotonic NaCl with a small increase in mucosal permeability. In control animals exhibiting spontaneous duodenal contractions, the bicarbonate secretion was 50% higher and the hypotonicity-induced net increase in mucosal permeability sevenfold higher than in 'paralytic' controls. Treatment with the selective COX-2 inhibitors rofecoxib or parecoxib induced duodenal motility, increased bicarbonate secretion and potentiated the hypotonicity-induced increase in mucosal permeability. COX-2-inhibited animals had a twofold greater capacity to adjust luminal osmolality than 'paraly...Continue Reading

References

Aug 1, 1978·The American Journal of Digestive Diseases·L BuenoY Ruckebusch
Nov 1, 1989·The Journal of Pharmacy and Pharmacology·M Pairet, Y Ruckebusch
Jan 1, 1994·The American Journal of Physiology·M Sababi, O Nylander
Feb 1, 1997·British Journal of Anaesthesia·P Sheeran, G M Hall
May 23, 1998·Annual Review of Pharmacology and Toxicology·J R VaneR M Botting
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·C J SmithP C Isakson
Jun 3, 1999·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E Husebye
Apr 3, 2001·Nature Medicine·N G Bazan
Oct 23, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·O NylanderM Sababi
Feb 22, 2002·Journal of Cellular Physiology·Yang Cao, Stephen M Prescott
Oct 2, 2002·Digestive Diseases and Sciences·Koji TakeuchiShoji Kawauchi
Apr 11, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Olof NylanderMichael Perry
Apr 23, 2003·European Journal of Pharmacology·Lars Göran AxelssonPer M Hellström
Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Brian Behm, Neil Stollman
Apr 23, 2004·European Journal of Pharmacology·Satyanarayana S V PadiShrinivas K Kulkarni
May 1, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Timothy D Warner, Jane A Mitchell
Jun 3, 2004·Langenbeck's Archives of Surgery·Michael D Menger, Brigitte Vollmar
Sep 11, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A J Bauer, G E Boeckxstaens
Sep 18, 2004·Cancer Letters·Shan ZhaAngelo M De Marzo
Dec 17, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E P BourasG M Thomforde
May 21, 2005·Toxicologic Pathology·Richard HaworthAndrew Pilling

❮ Previous
Next ❯

Citations

Oct 8, 2009·Pharmacology & Therapeutics·Matteo FornaiCorrado Blandizzi
Feb 7, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L BuenoN J Talley
Apr 25, 2017·Experimental Physiology·Wan Salman Wan Saudi, Markus Sjöblom
Jul 25, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Wan Salman Wan SaudiPer M Hellström

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.