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Products of the Parkinson’s-disease related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival

bioRxiv

Jul 4, 2014

Yusuke ToyodaTeymuras V Kurzchalia

Abstract

Parkinson’s disease is associated with mitochondrial decline in dopaminergic neurons of the substantia nigra . One of the genes, DJ-1/PARK7, linked with the onset of Parkinson’s disease, belongs to a novel glyoxalase family and influences mitochondrial activity. It has been assumed that...read more

Mentioned in this Paper

Metabolic Process, Cellular
Biochemical Pathway
PINK1
AN 1
PARK7
Genes
Mitochondrial Inheritance
Toxin
Neurons
D-Lactic Acid
6
Paper Details
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Products of the Parkinson’s-disease related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival

bioRxiv

Jul 4, 2014

Yusuke ToyodaTeymuras V Kurzchalia

PMID: 990006916

DOI: 10.1101/006916

Abstract

Parkinson’s disease is associated with mitochondrial decline in dopaminergic neurons of the substantia nigra . One of the genes, DJ-1/PARK7, linked with the onset of Parkinson’s disease, belongs to a novel glyoxalase family and influences mitochondrial activity. It has been assumed that...read more

Mentioned in this Paper

Metabolic Process, Cellular
Biochemical Pathway
PINK1
AN 1
PARK7
Genes
Mitochondrial Inheritance
Toxin
Neurons
D-Lactic Acid
6

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Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Related Papers

Movement Disorders : Official Journal of the Movement Disorder Society

Recessive Parkinson's disease

Movement Disorders : Official Journal of the Movement Disorder SocietyApril 15, 2006
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