Profibrinolytic activities of chemically modified heparins with very low anticoagulant activities

Thrombosis Research
R PortaG Prino


Many evidences indicate that heparin is an activator of fibrinolysis, but the most important side effect of heparin is bleeding which is a problem particularly in the high risk patient. Here we describe how chemical modifications, associated with separation techniques, can sharply reduce the anticoagulant activities of a heparin while its ability to stimulate fibrinolysis is retained.


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