Proficiency testing program for hemoglobin E, A2 and F analysis in Thailand using lyophilized hemoglobin control materials.

Clinical Chemistry and Laboratory Medicine : CCLM
Sakorn PornprasertKallayanee Treesuwan

Abstract

There is no external quality assessment (EQA) program for hemoglobin analysis that uses lyophilized hemoglobin control materials with HbA2/E in levels as high as those found in people with the β-thalassemia trait, HbE trait, β-thalassemia/HbE disease or homozygous HbE; these are all found frequently in the southeast Asian population. The aim of this study was to evaluate the efficiency of the control materials used in the established proficiency testing (PT) program at the Associated Medical Sciences-Clinical Service Center (AMC-CSC), Chiang Mai University, Chiang Mai, Thailand. The PT program for Hb analysis and the thalassemia interpretation was established in compliance with ISO/IEC17043:2010. Three cycles per year were performed in 2015 and 2016. In each cycle, three different types of control material were provided to the participants. Each participant analyzed the control materials in the same manner as in their routine practices. Hb analysis results and their thalassemia interpretation codes were entered into the report form and sent back to AMC-CSC. The number of participants increased from 63 in 2015 to 76 in 2016. In addition, the number of participants who took part in all three cycles increased from 95.2% (60/63) in...Continue Reading

References

Jan 1, 1988·Hemoglobin·S FucharoenV Thonglairuam
Jul 8, 1999·The New England Journal of Medicine·N F Olivieri
Aug 25, 2004·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S SirichotiyakulTheera Tongsong
Dec 13, 2005·Annals of the New York Academy of Sciences·Elliott P Vichinsky
Jun 3, 2009·International Journal of Laboratory Hematology·P Van DelftP C Giordano
Feb 23, 2011·International Journal of Laboratory Hematology·Goonnapa FucharoenS Fucharoen
Dec 18, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Rossarin KarnpeanS Fucharoen
Dec 5, 2014·Blood Cells, Molecules & Diseases·Supawadee YamsriS Fucharoen

Methods Mentioned

BETA
PCR
electrophoresis

Related Concepts

Fetal Hemoglobin
Hemoglobin A2
Hemoglobin E
Thalassemia
Laboratory Proficiency Testing
Freeze Drying
Hemoglobin A2
Hemoglobin E
Hemoglobin
Persons

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